Folate supplementation in rats: Does it cause behavioural and electrophysiological changes?

Terken Baydar, A. Papp, L. Nagymajtényi, Horst Schulz, Gonul Sahin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Folate supplementation is becoming increasingly popular not only to decrease homocystein, a long with the finding that moderate hyperhomocysteinaemia is a cardiovascular risk factor but also diminish some other risks related to folate depletion. The aim of the study was to investigate whether folic acid supplementation leads to behavioural and electrophysiological changes in rats. Therefore, 30 male Wistar rats were divided to three groups. Each of animal groups was consisted of 10 animals. Folic acid was applied to rats by gavage for 8 weeks. Group I as a control group was taking folic acid-free water by gavage throughout the duration of the experiment. Groups II and III were treated with 2.0 mg/kg/day and 20.0 mg/kg/day of folic acid, respectively. Behavioural effects were evaluated by open field motor activity and by acoustic startle response. Electrophysiological examination was done by recording spontaneous activity and sensory evoked potentials from the visual, somatosensory, as well as auditory cortex. No significant effects on motor activity or acoustic startle response were observed. Both doses of folic acid shortened the latency of the visual cortical evoked potential (p

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalPteridines
Volume13
Issue number4
Publication statusPublished - Dec 2002

Fingerprint

Folic Acid
Rats
Startle Reflex
Bioelectric potentials
Acoustics
Animals
Motor Activity
Hyperhomocysteinemia
Auditory Cortex
Somatosensory Cortex
Visual Evoked Potentials
Visual Cortex
Evoked Potentials
Wistar Rats
Control Groups
Water
Experiments

Keywords

  • Behaviour
  • Electrophysiology
  • Folic acid
  • Rat
  • Subchronic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Folate supplementation in rats : Does it cause behavioural and electrophysiological changes? / Baydar, Terken; Papp, A.; Nagymajtényi, L.; Schulz, Horst; Sahin, Gonul.

In: Pteridines, Vol. 13, No. 4, 12.2002, p. 107-114.

Research output: Contribution to journalArticle

Baydar, Terken ; Papp, A. ; Nagymajtényi, L. ; Schulz, Horst ; Sahin, Gonul. / Folate supplementation in rats : Does it cause behavioural and electrophysiological changes?. In: Pteridines. 2002 ; Vol. 13, No. 4. pp. 107-114.
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