Folate deficiency and folic acid supplementation: The prevention of neural-tube defects and congenital heart defects

E. Czeizel, Istvan Dudás, Attila Vereczkey, F. Bánhidy

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention (randomized double-blind and cohort controlled) trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion (about 90%) of neural-tube defects (NTD) as well as a certain proportion (about 40%) of congenital heart defects. Finally the benefits and drawbacks of three main practical applications of folic acid/multivitamin treatment such as (i) dietary intake; (ii) periconceptional supplementation; and (iii) flour fortification are discussed. The conclusion arrived at is indeed confirmation of Benjamin Franklin's statement: "An ounce of prevention is better than a pound of care".

Original languageEnglish
Pages (from-to)4760-4775
Number of pages16
JournalNutrients
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 21 2013

Fingerprint

Folic Acid Deficiency
vitamin deficiencies
Avitaminosis
neural tube defects
Neural Tube Defects
Congenital Heart Defects
Folic Acid
folic acid
heart
Flour
flour
food intake
Diet
diet

Keywords

  • Congenital heart defects
  • Folic acid
  • Multivitamins
  • Neural-tube defects
  • Primary prevention

ASJC Scopus subject areas

  • Food Science

Cite this

Folate deficiency and folic acid supplementation : The prevention of neural-tube defects and congenital heart defects. / Czeizel, E.; Dudás, Istvan; Vereczkey, Attila; Bánhidy, F.

In: Nutrients, Vol. 5, No. 11, 21.11.2013, p. 4760-4775.

Research output: Contribution to journalArticle

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