Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents

The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

I. Iglesia, I. Huybrechts, M. González-Gross, T. Mouratidou, J. Santabárbara, V. Chajès, E. M. González-Gil, J. Y. Park, S. Bel-Serrat, M. Cuenca-García, M. Castillo, M. Kersting, K. Widhalm, S. De Henauw, M. Sjöström, F. Gottrand, D. Molnár, Y. Manios, A. Kafatos, M. Ferrari & 4 others P. Stehle, A. Marcos, F. J. Sánchez-Muniz, L. A. Moreno

Research output: Contribution to journalArticle

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Abstract

This study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found with n-6:n-3 ratio, trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15·85 Âmol/l of EPA (P value <0·01), whereas an increase of 10 nmol/l of tHcy in males produces a decrease of 2·06 Âmol/l of DHA (P value <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlying mechanisms between B-vitamins and CVD and it is worth the attention of public health policies.

Original languageEnglish
Pages (from-to)124-133
Number of pages10
JournalBritish Journal of Nutrition
Volume117
Issue number1
DOIs
Publication statusPublished - Jan 14 2017

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Vitamin B Complex
Vitamin B 12
Folic Acid
Fatty Acids
Biomarkers
Homocysteine
Trans Fatty Acids
Vitamin B 6
Omega-3 Fatty Acids
Public Policy
Health Policy
Healthy Lifestyle
Immunoassay
Chromatography
Linear Models
Public Health
Erythrocytes
Mothers
Exercise
Diet

Keywords

  • Adolescents
  • B-vitamins
  • Europe
  • Fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. / Iglesia, I.; Huybrechts, I.; González-Gross, M.; Mouratidou, T.; Santabárbara, J.; Chajès, V.; González-Gil, E. M.; Park, J. Y.; Bel-Serrat, S.; Cuenca-García, M.; Castillo, M.; Kersting, M.; Widhalm, K.; De Henauw, S.; Sjöström, M.; Gottrand, F.; Molnár, D.; Manios, Y.; Kafatos, A.; Ferrari, M.; Stehle, P.; Marcos, A.; Sánchez-Muniz, F. J.; Moreno, L. A.

In: British Journal of Nutrition, Vol. 117, No. 1, 14.01.2017, p. 124-133.

Research output: Contribution to journalArticle

Iglesia, I, Huybrechts, I, González-Gross, M, Mouratidou, T, Santabárbara, J, Chajès, V, González-Gil, EM, Park, JY, Bel-Serrat, S, Cuenca-García, M, Castillo, M, Kersting, M, Widhalm, K, De Henauw, S, Sjöström, M, Gottrand, F, Molnár, D, Manios, Y, Kafatos, A, Ferrari, M, Stehle, P, Marcos, A, Sánchez-Muniz, FJ & Moreno, LA 2017, 'Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study', British Journal of Nutrition, vol. 117, no. 1, pp. 124-133. https://doi.org/10.1017/S0007114516004414
Iglesia, I. ; Huybrechts, I. ; González-Gross, M. ; Mouratidou, T. ; Santabárbara, J. ; Chajès, V. ; González-Gil, E. M. ; Park, J. Y. ; Bel-Serrat, S. ; Cuenca-García, M. ; Castillo, M. ; Kersting, M. ; Widhalm, K. ; De Henauw, S. ; Sjöström, M. ; Gottrand, F. ; Molnár, D. ; Manios, Y. ; Kafatos, A. ; Ferrari, M. ; Stehle, P. ; Marcos, A. ; Sánchez-Muniz, F. J. ; Moreno, L. A. / Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. In: British Journal of Nutrition. 2017 ; Vol. 117, No. 1. pp. 124-133.
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