Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

I. Iglesia, I. Huybrechts, M. González-Gross, T. Mouratidou, J. Santabárbara, V. Chajès, E. M. González-Gil, J. Y. Park, S. Bel-Serrat, M. Cuenca-García, M. Castillo, M. Kersting, K. Widhalm, S. De Henauw, M. Sjöström, F. Gottrand, D. Molnár, Y. Manios, A. Kafatos, M. FerrariP. Stehle, A. Marcos, F. J. Sánchez-Muniz, L. A. Moreno

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Abstract

This study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found with n-6:n-3 ratio, trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15·85 Âmol/l of EPA (P value <0·01), whereas an increase of 10 nmol/l of tHcy in males produces a decrease of 2·06 Âmol/l of DHA (P value <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlying mechanisms between B-vitamins and CVD and it is worth the attention of public health policies.

Original languageEnglish
Pages (from-to)124-133
Number of pages10
JournalBritish Journal of Nutrition
Volume117
Issue number1
DOIs
Publication statusPublished - Jan 14 2017

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Keywords

  • Adolescents
  • B-vitamins
  • Europe
  • Fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Iglesia, I., Huybrechts, I., González-Gross, M., Mouratidou, T., Santabárbara, J., Chajès, V., González-Gil, E. M., Park, J. Y., Bel-Serrat, S., Cuenca-García, M., Castillo, M., Kersting, M., Widhalm, K., De Henauw, S., Sjöström, M., Gottrand, F., Molnár, D., Manios, Y., Kafatos, A., ... Moreno, L. A. (2017). Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. British Journal of Nutrition, 117(1), 124-133. https://doi.org/10.1017/S0007114516004414