FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia

Tünde Hidvégi, Gennadi A. Ermolin, Evgeni E. Efremov, Michail M. Dikov, Ludmilla V. Kurmanova, Galina V. Vnashenkova, Marina V. Merkulova, Márta Kókai, Aranka Panya, George Füst

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9 Citations (Scopus)

Abstract

We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalImmunology letters
Volume22
Issue number1
DOIs
Publication statusPublished - Jul 1989

Keywords

  • C1 INH
  • C1rC1s
  • CLL
  • FN-C1q complexes
  • Hypocomplementaemia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Hidvégi, T., Ermolin, G. A., Efremov, E. E., Dikov, M. M., Kurmanova, L. V., Vnashenkova, G. V., Merkulova, M. V., Kókai, M., Panya, A., & Füst, G. (1989). FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia. Immunology letters, 22(1), 1-6. https://doi.org/10.1016/0165-2478(89)90133-8