FMRFamide-related peptides: Anti-opiate transmitters acting in apoptosis

Tamás Rszer, G. Bánfalvi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Members of the FMRFamide-related peptide (FaRP) family are neurotransmitters, hormone-like substances and tumor suppressor peptides. In mammals, FaRPs are considered as anti-opiate peptides due to their ability to inhibit opioid signaling. Some FaRPs are asserted to attenuate opiate tolerance. A recently developed chimeric FaRP (Met-enkephalin-FMRFa) mimics the analgesic effects of opiates without the development of opiate-dependence, displaying a future therapeutical potential in pain reduction. In this review we support the notion, that opiates and representative members of the FaRP family show overlapping effects on apoptosis. Binding of FaRPs to opioid receptors or to their own receptors (G-protein linked membrane receptors and acid-sensing ion channels) evokes or suppresses cell death, in a cell- and receptor-type manner. With the dramatically increasing incidence of opiate abuse and addiction, understanding of opioid-induced cell death, and in this context FaRPs will deserve growing attention.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalPeptides
Volume34
Issue number1
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Opiate Alkaloids
FMRFamide
Opioid Peptides
Transmitters
Apoptosis
Opioid-Related Disorders
Peptides
Opioid Analgesics
Cell death
Cell Death
Acid Sensing Ion Channels
Methionine Enkephalin
Aptitude
Opioid Receptors
GTP-Binding Proteins
Mammals
Neurotransmitter Agents
Analgesics
Hormones
Tumors

Keywords

  • ASIC
  • Cell death
  • GPR10
  • GPR54
  • Kisspeptins
  • NPFF-receptor
  • Opiates
  • Opioid receptors
  • RF-amides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

FMRFamide-related peptides : Anti-opiate transmitters acting in apoptosis. / Rszer, Tamás; Bánfalvi, G.

In: Peptides, Vol. 34, No. 1, 03.2012, p. 177-185.

Research output: Contribution to journalArticle

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