The author resports on the results of 20 mg/day of fluoxetine treatment of patients with DSM-III-R unipolar major depression over 65 years of age. Out of the 113 patients included into the open, non-comparative prospective study, performed in 15 Hungarian psychiatric centers, 105 persons (93%) completed the 12-weeks trial. More than 80 percent of the patients were females and the mean age was 72,0 years. The rate of responders at the end of week 3 and 12 was 26 percent and 77 percent respectively. Compared to baseline, the mean total Hamilton Depression Scores decreased to the half at week 3, and to the third at week 12. The frequency of side-effects related to fluoxetine was 21 percent at week 3 and 13 percent at week 12. Only 4 patients (4%) stopped the fluoxetine because of the side-effects. The results are in agreement with the international data and suggest that 20 mg/day fluoxetine (either as monotherapy or in combination with other drugs) is an effective, well-tolerable and safe treatment for elderly patients with major depression.
|Number of pages||7|
|Publication status||Published - Jan 1 1999|
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