Fluorous click chemistry as a practical tagging method

Zoltán Kaleta, O. Egyed, T. Soós

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A fluorous version of azide click chemistry was developed and its utility was demonstrated in the synthesis of the fluorous cinchona alkaloid. Highly efficient fluorous tagging methodology was developed based on catalytic 1,3-dipolar cycloaddition as the key step. This method resulted in high yield, utilized mild reaction conditions and had a high functional group tolerance and chemoselectivity. The successful application of click chemistry to fluorous chemistry gave an impetus to demonstrate its utility in the fluorous synthesis of a more complex molecule. The fluorous tagging procedure offered an improvement in both efficiency and practical simplicity.

Original languageEnglish
Pages (from-to)2228-2230
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number12
DOIs
Publication statusPublished - Jun 21 2005

Fingerprint

Click Chemistry
marking
Cinchona Alkaloids
chemistry
Azides
Cycloaddition Reaction
alkaloids
Cycloaddition
cycloaddition
synthesis
Functional groups
methodology
Molecules
molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Cite this

Fluorous click chemistry as a practical tagging method. / Kaleta, Zoltán; Egyed, O.; Soós, T.

In: Organic and Biomolecular Chemistry, Vol. 3, No. 12, 21.06.2005, p. 2228-2230.

Research output: Contribution to journalArticle

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