Fluorinated diketo phosphorus ylides are novel inhibitors of the abcb1 efflux pump of cancer cells

Gabriella Spengler, Imre Ocsovszki, Ádám Szabó Tonki, Ryosuke Saijo, Genki Watanabe, Masami Kawase, Joseph Molnár

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Efflux pump inhibitors are attractive compounds that reverse multidrug resistance (MDR) in cancer cells. In the present study, 10 phosphorus ylides (P-ylides) were compared based on their MDR-reverting activity in human ATP-binding cassette sub-family B member 1 (ABCB1; Pglycoprotein) gene-transfected L5178Y mouse T-lymphoma cells. Among them, three P-ylides, Ph3P=C(COCF3)COPh, Ph3P=C(COC2F5)COPh and Ph3P=C(COC3F7)COPh were identified as selectively modulating the ABCB1 pump. These compounds, with low cytotoxicity against mouse Tlymphoma cells, exhibited more potency than the positive control ABCB1 inhibitor verapamil.

Original languageEnglish
Pages (from-to)5915-5919
Number of pages5
JournalAnticancer research
Volume35
Issue number11
Publication statusPublished - Nov 2015

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Keywords

  • ABCB1
  • Mouse T-lymphoma
  • Multidrug resistance
  • P-glycoprotein
  • Phosphorus ylide
  • Trifluoroacetyl

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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