Fluorescence in situ hybridization reveals trisomy 2q by insertion into 9p in hepatoblastoma

E. Balogh, S. Swanton, C. Kiss, Z. S. Jakab, L. M. Secker-Walker, É Oláh

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15 Citations (Scopus)


Cytogenetics and fluorescence in situ hybridization (FISH) of a hepatoblastoma are presented. The results of standard chromosome analysis were as follows: 47,XY,+2,add(4)(q35),-9,+20[10]. FISH with the use of whole- chromosome paints revealed partial trisomy of the long arm of chromosome 2 by insertion into chromosome 9. Comparison of the G-banded metaphases with metaphase FISH led to a reinterpretation of the karyotype as: 47,XY, add(4)(q35),der(9)ins(9;2)(p22;q?21q?25),+20. This case supports previous observations that the critical region of trisomy 2 lies between 2q21 and 2qter and shows how partial trisomy 2q may evade detection in G-banded metaphases.

Original languageEnglish
Pages (from-to)148-150
Number of pages3
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - Apr 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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