A fluoreszcens in situ hibridizáció alkalmazása a praenatalis diagnosztikában. Elsö tapasztalatok.

Translated title of the contribution: Fluorescence in situ hybridization in prenatal diagnosis. First experiences

E. Tardy, A. Tóth, K. Hajdu, S. Gombos, J. László

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The authors examined the potential use of non-radioactive in situ hybridization in prenatal screening. Probes for chromosomes 18, 13/21, 21 and X were applied on fourteen samples of peripheral lymphocytes and nine samples of chorionic villi. The aim of the study was to compare the analyzability of the two different DNA probes for chromosome 21 on six samples of chorionic villi. Six of the nine samples of chorionic villi were hybridized with probes specific for chromosome 21 and all six cases were diagnosed properly. However, we need more data to establish a screening protocol for routine prenatal cytogenetics.

Original languageHungarian
Pages (from-to)523-526
Number of pages4
JournalOrvosi hetilap
Volume137
Issue number10
Publication statusPublished - Mar 10 1996

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ASJC Scopus subject areas

  • Medicine(all)

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