Fluid Therapy: Double-Edged Sword during Critical Care?

Jan Benes, Mikhail Kirov, Vsevolod Kuzkov, Mitja Lainscak, Z. Molnár, Gorazd Voga, Xavier Monnet

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Fluid therapy is still the mainstay of acute care in patients with shock or cardiovascular compromise. However, our understanding of the critically ill pathophysiology has evolved significantly in recent years.The revelation of the glycocalyx layer and subsequent research has redefined the basics of fluids behavior in the circulation. Using less invasive hemodynamic monitoring tools enables us to assess the cardiovascular function in a dynamic perspective. This allows pinpointing even distinct changes induced by treatment, by postural changes, or by interorgan interactions in real time and enables individualized patient management. Regarding fluids as drugs of any other kind led to the need for precise indication, way of administration, and also assessment of side effects.We possess now the evidence that patient centered outcomes may be altered when incorrect time, dose, or type of fluids are administered. In this review, three major features of fluid therapy are discussed: the prediction of fluid responsiveness, potential harms induced by overzealous fluid administration, and finally the problem of protocol-led treatments and their timing.

Original languageEnglish
Article number729075
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Fluid Therapy
Critical Care
Glycocalyx
Fluids
Clinical Protocols
Critical Illness
Shock
Patient Care
Hemodynamics
Research
Pharmaceutical Preparations
Therapeutics
Lead
Monitoring

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Benes, J., Kirov, M., Kuzkov, V., Lainscak, M., Molnár, Z., Voga, G., & Monnet, X. (2015). Fluid Therapy: Double-Edged Sword during Critical Care? BioMed Research International, 2015, [729075]. https://doi.org/10.1155/2015/729075

Fluid Therapy : Double-Edged Sword during Critical Care? / Benes, Jan; Kirov, Mikhail; Kuzkov, Vsevolod; Lainscak, Mitja; Molnár, Z.; Voga, Gorazd; Monnet, Xavier.

In: BioMed Research International, Vol. 2015, 729075, 2015.

Research output: Contribution to journalArticle

Benes, J, Kirov, M, Kuzkov, V, Lainscak, M, Molnár, Z, Voga, G & Monnet, X 2015, 'Fluid Therapy: Double-Edged Sword during Critical Care?', BioMed Research International, vol. 2015, 729075. https://doi.org/10.1155/2015/729075
Benes, Jan ; Kirov, Mikhail ; Kuzkov, Vsevolod ; Lainscak, Mitja ; Molnár, Z. ; Voga, Gorazd ; Monnet, Xavier. / Fluid Therapy : Double-Edged Sword during Critical Care?. In: BioMed Research International. 2015 ; Vol. 2015.
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