Fluid replacement and respiratory function

Comparison of whole blood with colloid and crystalloid

Gergely H. Fodor, Barna Babik, Dorottya Czövek, Camille Doras, Ádám L. Balogh, Sam Bayat, Walid Habre, F. Peták

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND Fluid replacement with blood products, colloids and crystalloids is abociated with morbidity and mortality. Despite this, the consequences of fluid administration on airway and respiratory tibue properties are not fully understood. OBJECTIVE Comparison of respiratory effects of fluid replacement with autologous blood (Group B), colloid (HES 6% 130/0.4, Group CO) or crystalloid solution (NaCl 0.9%, Group CR) after haemorrhage with separate abebments of airway resistance and respiratory tibue mechanics. DESIGN A randomised study. SETTING An experimental model of surgical haemorrhage and fluid replacement in rats. PARTICIPANTS Anaesthetised, ventilated rats randomly allocated into three groups (Group B: n=8, Group CO: n=8, Group CR: n=9). INTERVENTION Animals were bled in six sequential steps, each manoeuvre targeting a lob of 5% of total blood volume. The blood lob was then replaced stepwise in a 1:1 ratio with one of the three fluids. MAIN OUTCOME MEASURE After each step, airway resistance (Raw), tibue damping and elastance (H) were determined by forced oscillations. Oedema indices from lung weights and histology were also measured. RESULTS Raw (mean±SD) decreased in all groups following blood lob (-20.3±9.5% vs. baseline, P

Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalEuropean Journal of Anaesthesiology
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Airway Resistance
Colloids
Carbon Monoxide
Blood Group Antigens
Surgical Blood Loss
Respiratory Mechanics
Blood Volume
Edema
Histology
Theoretical Models
Hemorrhage
Morbidity
Weights and Measures
Lung
Mortality
crystalloid solutions
HES 130-0.4

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Fluid replacement and respiratory function : Comparison of whole blood with colloid and crystalloid. / Fodor, Gergely H.; Babik, Barna; Czövek, Dorottya; Doras, Camille; Balogh, Ádám L.; Bayat, Sam; Habre, Walid; Peták, F.

In: European Journal of Anaesthesiology, Vol. 33, No. 1, 01.01.2016, p. 34-41.

Research output: Contribution to journalArticle

Fodor, Gergely H. ; Babik, Barna ; Czövek, Dorottya ; Doras, Camille ; Balogh, Ádám L. ; Bayat, Sam ; Habre, Walid ; Peták, F. / Fluid replacement and respiratory function : Comparison of whole blood with colloid and crystalloid. In: European Journal of Anaesthesiology. 2016 ; Vol. 33, No. 1. pp. 34-41.
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