Flow motion pattern differences in the forehead and forearm skin: Age-dependent alterations are not specific for Alzheimer's disease

Ferenc Bari, Valéria Tóth-Szuki, Ferenc Domoki, János Kálmán

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Oscillations in laser Doppler signals derived from the forehead and forearm skin were analyzed in 77 healthy probands from 4 various age groups (ranging between 15 and 77 years) and 22 late-onset sporadic Alzheimer's disease (AD) patients. A characteristic pattern of oscillations in the microcirculatory blood flux (∼8 cycles/min, 0.13 Hz) was observed in the forehead skin, the occurrence of which correlated inversely with age (r = 0.80). The occurrence of forehead vasomotion pattern was 100% in the teenagers, whereas it was significantly less in the elderly control subjects (32%) and in the AD patients (18%). Forearm reactive hyperemia was provoked by 1-min occlusion of the brachial artery, and the vascular reactivity was calculated. This phenomenon also proved to be age-dependent, but the process was not related to AD. Our results indicate that the lack of forehead vasomotion reflects aging better than does the forearm vasomotion. Both of these functions are preserved in AD.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalMicrovascular Research
Volume70
Issue number3
DOIs
Publication statusPublished - Nov 1 2005

Keywords

  • Alzheimer's disease
  • Blood flow
  • Laser Doppler
  • Skin
  • Vascular reactivity
  • Vasomotion

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'Flow motion pattern differences in the forehead and forearm skin: Age-dependent alterations are not specific for Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this