Flow-chemistry enabled efficient synthesis of β-peptides: Backbone topology: Vs. helix formation

Imane Nekkaa, Dóra Bogdán, Tamás Gáti, S. Béni, T. Juhász, Márta Palkó, Gábor Paragi, G. Tóth, F. Fülöp, I. Mándity

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Enantiodiscriminative helix formation was observed for β-peptide H14 helices. This observation is caused by the synperiplanar orientation of H-O atoms which is more unfavorable than those for H-H interaction. The 1,2 H-O interaction leads to the destruction of the helical structure. The introduction of a double C-C bond in the backbone rules out helix formation.

Original languageEnglish
Pages (from-to)3061-3064
Number of pages4
JournalChemical Communications
Volume55
Issue number21
DOIs
Publication statusPublished - Jan 1 2019

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Peptides
Topology
Atoms

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Flow-chemistry enabled efficient synthesis of β-peptides : Backbone topology: Vs. helix formation. / Nekkaa, Imane; Bogdán, Dóra; Gáti, Tamás; Béni, S.; Juhász, T.; Palkó, Márta; Paragi, Gábor; Tóth, G.; Fülöp, F.; Mándity, I.

In: Chemical Communications, Vol. 55, No. 21, 01.01.2019, p. 3061-3064.

Research output: Contribution to journalArticle

Nekkaa, Imane ; Bogdán, Dóra ; Gáti, Tamás ; Béni, S. ; Juhász, T. ; Palkó, Márta ; Paragi, Gábor ; Tóth, G. ; Fülöp, F. ; Mándity, I. / Flow-chemistry enabled efficient synthesis of β-peptides : Backbone topology: Vs. helix formation. In: Chemical Communications. 2019 ; Vol. 55, No. 21. pp. 3061-3064.
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