Flow-chemistry enabled efficient synthesis of β-peptides: Backbone topology: Vs. helix formation

Imane Nekkaa, Dóra Bogdán, Tamás Gáti, Szabolcs Béni, Tünde Juhász, Márta Palkó, Gábor Paragi, Gábor K. Tóth, Ferenc Fülöp, István M. Mándity

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Enantiodiscriminative helix formation was observed for β-peptide H14 helices. This observation is caused by the synperiplanar orientation of H-O atoms which is more unfavorable than those for H-H interaction. The 1,2 H-O interaction leads to the destruction of the helical structure. The introduction of a double C-C bond in the backbone rules out helix formation.

Original languageEnglish
Pages (from-to)3061-3064
Number of pages4
JournalChemical Communications
Volume55
Issue number21
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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