Flow chemistry as a versatile tool for the synthesis of triazoles

Sándor B. Ötvös, Ferenc Fülöp

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Continuous-flow processing offers unprecedented opportunities to accelerate, integrate, simplify, scale-up and automatize chemical reactions, in combination with an inherently safer and 'greener' nature over traditional batch-based syntheses. Triazoles are amongst the most important and most intensively studied heterocycles due to their diverse biological activities and incredible number of applications in labeling, modification and synthesis of various biomolecules, polymers and supramolecular assemblies. Many research groups have demonstrated that both copper-catalyzed and catalyst-free cycloadditions between azides and various dipolarophiles leading to triazoles or triazole-based structures can be greatly facilitated through the beneficial features of continuous-flow processing. The present review therefore surveys the flow chemistry-based approaches for the synthesis of triazoles, covering the most important catalytic and catalyst-free strategies in continuously operated systems published during the past decade.

Original languageEnglish
Pages (from-to)4926-4941
Number of pages16
JournalCatalysis Science and Technology
Volume5
Issue number11
DOIs
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Catalysis

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