Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity

Orsolya Roza, Ana Martins, Judit Hohmann, Wan Chun Lai, Jacobus Eloff, Fang Rong Chang, Dezső Csupor

Research output: Contribution to journalArticle

Abstract

The present paper reports the chemical analysis of the methanolic extracts of fermented and non-fermented Cyclopia genistoides herbs and an investigation of the xanthine oxidase inhibitory activity of the isolated constituents. Chemical analysis of the leaves and stems of C. genistoides yielded the isolation and identification of two benzophenone glucosides, iriflophenone 2-O-β-glucopyranoside (1) and iriflophenone 3-C-β-glucopyranoside (2), two pterocarpans, (6aR,11aR)-(−)-2-methoxymaackiain (5) and (6aR,11aR)-(−)-maackiain (6), along with the flavanones liquiritigenin (9) and hesperetin (10), the flavone diosmetin (11), the isoflavones afrormosin (7) and formononetin (8), piceol (3), and 4-hydroxybenzaldehid (4). Among the eleven compounds, nine are reported for the first time from this species, and six from the genus Cyclopia. These compounds, together with previously isolated secondary metabolites of this species, were tested for xanthine oxidase inhibitory activity. The 5,7-dihydroxyflavones luteolin and diosmetin significantly inhibited the enzyme in vitro, while hesperetin (10) and 5,7,3′,5′-tetrahydroxyflavone exerted weak activity.

Original languageEnglish
JournalPlanta Medica
DOIs
StateAccepted/In press - Jun 11 2016

Fingerprint

Xanthine Oxidase
Flavonoids
African horse sickness virus
Pterocarpans
Flavanones
Luteolin
Isoflavones
Glucosides
Enzymes
In Vitro Techniques
MSH Release-Inhibiting Hormone

Keywords

  • benzophenone
  • Cyclopia genistoides
  • Fabaceae
  • flavonoid
  • gout
  • honeybush
  • xanthine oxidase

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Roza, O., Martins, A., Hohmann, J., Lai, W. C., Eloff, J., Chang, F. R., & Csupor, D. (2016). Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity. Planta Medica. DOI: 10.1055/s-0042-110656

Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity. / Roza, Orsolya; Martins, Ana; Hohmann, Judit; Lai, Wan Chun; Eloff, Jacobus; Chang, Fang Rong; Csupor, Dezső.

In: Planta Medica, 11.06.2016.

Research output: Contribution to journalArticle

Roza O, Martins A, Hohmann J, Lai WC, Eloff J, Chang FR et al. Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity. Planta Medica. 2016 Jun 11. Available from, DOI: 10.1055/s-0042-110656

Roza, Orsolya; Martins, Ana; Hohmann, Judit; Lai, Wan Chun; Eloff, Jacobus; Chang, Fang Rong; Csupor, Dezső / Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity.

In: Planta Medica, 11.06.2016.

Research output: Contribution to journalArticle

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