Flavonoids alter bone-remodelling in auditory ossicle organ cultures

István Sziklai, Ottó Ribári

Research output: Contribution to journalArticle

5 Citations (Scopus)


The beneficial role of bioflavonoids in an otosclerosis-like bone-remodelling process can be implicated from its interference with bone resorption induced by prostaglandin E2 (PGE2) in cultured guinea pig ossicles. Ipriflavone (7-isopropoxy-isoflavon) and quercetin reduced PGE2-elevated collagenase-like peptidase (Cl-peptidase) activity and potentiated a PGE2-induced decrease in collagen synthesis. The fact that PGE2 effects are mediated through cyclic AMP in bone turnover and flavonoids act synergistically with PGE2 in collagen synthesis confirm a cyclic AMP phosphodiesterase inhibitory role of flavonoids. It has already been attempted to use Ipriflavone medical treatment of otosclerosis. Quercetine, which has a better than Ipriflavone water-solubility seems as promising as Ipriflavone in the control of the otosclerotic bone-remodelling disturbance.

Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalActa Oto-Laryngologica
Issue number2
Publication statusPublished - Jan 1 1995


  • Bone resorption
  • Cl-peptidase
  • Collagen synthesis
  • Flavonoid
  • Otosclerosis

ASJC Scopus subject areas

  • Otorhinolaryngology

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