Flat control of tumor growth with angiogenic inhibition

Daniel A. Drexler, Johanna Sápi, Annamária Szeles, István Harmati, Adalbert Kovács, Levente Kovács

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Abstract

Cancer represents nowadays one of the most destructive and lethal illnesses of our civilization. In the last decades, clinical cancer research shifted towards molecular targeted therapies which have limited side effects in comparison to conventional chemotherapy and radiation therapy. Anti-angiogenic therapy is proved to be one of the most promising cancer treatment methods. This paper concerns on the model-based control of tumor growth under angiogenic inhibition. The tumor growth model is nonlinear, augmented with a linear model representing the pharmacokinetics of the applied inhibitor in tumor treatment. The control strategy is based on feedback linearization and path tracking. The result are compared with other, basically linear control strategies which were previously published by our group.

Original languageEnglish
Title of host publicationSACI 2012 - 7th IEEE International Symposium on Applied Computational Intelligence and Informatics, Proceedings
Pages179-183
Number of pages5
Publication statusPublished - Oct 3 2012
Event7th IEEE International Symposium on Applied Computational Intelligence and Informatics, SACI 2012 - Timisoara, Romania
Duration: May 24 2012May 26 2012

Publication series

NameSACI 2012 - 7th IEEE International Symposium on Applied Computational Intelligence and Informatics, Proceedings

Conference

Conference7th IEEE International Symposium on Applied Computational Intelligence and Informatics, SACI 2012
CountryRomania
CityTimisoara
Period5/24/125/26/12

    Fingerprint

ASJC Scopus subject areas

  • Artificial Intelligence
  • Information Systems

Cite this

Drexler, D. A., Sápi, J., Szeles, A., Harmati, I., Kovács, A., & Kovács, L. (2012). Flat control of tumor growth with angiogenic inhibition. In SACI 2012 - 7th IEEE International Symposium on Applied Computational Intelligence and Informatics, Proceedings (pp. 179-183). (SACI 2012 - 7th IEEE International Symposium on Applied Computational Intelligence and Informatics, Proceedings).