Fitness landscapes of functional RNAs

Ádám Kun, E. Szathmáry

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The notion of fitness landscapes, a map between genotype and fitness, was proposed more than 80 years ago. For most of this time data was only available for a few alleles, and thus we had only a restricted view of the whole fitness landscape. Recently, advances in genetics and molecular biology allow a more detailed view of them. Here we review experimental and theoretical studies of fitness landscapes of functional RNAs, especially aptamers and ribozymes. We find that RNA structures can be divided into critical structures, connecting structures, neutral structures and forbidden structures. Such characterisation, coupled with theoretical sequence-to-structure predictions, allows us to construct the whole fitness landscape. Fitness landscapes then can be used to study evolution, and in our case the development of the RNA world.

Original languageEnglish
Pages (from-to)1497-1517
Number of pages21
JournalLife
Volume5
Issue number3
DOIs
Publication statusPublished - Aug 21 2015

Fingerprint

fitness
RNA
Nucleotide Aptamers
Catalytic RNA
Molecular biology
Molecular Biology
Theoretical Models
Alleles
Genotype
molecular biology
genetic improvement
theoretical study
biology
allele
alleles
genotype
experimental study
prediction
predictions
Genetics

Keywords

  • Aptamer
  • Fitness landscape
  • Origin of life
  • Ribozyme
  • RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Palaeontology
  • Space and Planetary Science

Cite this

Fitness landscapes of functional RNAs. / Kun, Ádám; Szathmáry, E.

In: Life, Vol. 5, No. 3, 21.08.2015, p. 1497-1517.

Research output: Contribution to journalArticle

Kun, Ádám ; Szathmáry, E. / Fitness landscapes of functional RNAs. In: Life. 2015 ; Vol. 5, No. 3. pp. 1497-1517.
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