Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study

David Jiménez-Pavón, Manuel J. Castillo, Luis A. Moreno, Anthony Kafatos, Yannis Manios, Katerine Kondaki, Laurent Béghin, Maria Zaccaria, Stefaan De Henauw, Kurt Widhalm, D. Molnár, Michael Sjöström, Marcela González-Gross, Jonatan R. Ruiz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective. To examine the independent association of total and central body fat and cardiorespiratory fitness with markers of insulin resistance after controlling for several potential confounders in European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional) study. Methods. We conducted a cross sectional study (the HELENA-CSS) which comprised 1053 (12.517.5 years) adolescents from 10 European cities. Weight, height, waist circumference and skinfold thickness were measured, and body mass index (BMI) was calculated. Cardiorespiratory fitness was measured by the 20-m shuttle run test. Markers of insulin resistance were fasting insulin and glucose, and homeostasis model assessment (HOMA). Results. HOMA and insulin were positively associated with BMI, skinfolds and waist circumference after controlling for center, age, pubertal status and cardiorespiratory fitness (all P ≤ 0.01). HOMA and insulin were negatively associated with cardiorespiratory fitness in adolescents with moderate to high levels of total and central body fat (all P ≤ 0.01). Conclusions. HOMA and insulin were associated with total and central body fat in European adolescents. Moreover, cardiorespiratory fitness explained a part of the HOMA and insulin variance in those adolescents with moderate to high levels of total and central body fat, and also, to some extent, in those with low to middle fat mass.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalInternational Journal of Pediatric Obesity
Volume6
Issue number3-4
DOIs
Publication statusPublished - Aug 2011

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Insulin Resistance
Homeostasis
Insulin
Adipose Tissue
Waist Circumference
Body Mass Index
Cross-Sectional Studies
Skinfold Thickness
Fasting
Fats
Cardiorespiratory Fitness
Weights and Measures
Glucose

Keywords

  • Cardiorespiratory fitness
  • Glucose
  • HOMA
  • Insulin
  • Total and central body fat

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Health Policy
  • Nutrition and Dietetics

Cite this

Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study. / Jiménez-Pavón, David; Castillo, Manuel J.; Moreno, Luis A.; Kafatos, Anthony; Manios, Yannis; Kondaki, Katerine; Béghin, Laurent; Zaccaria, Maria; De Henauw, Stefaan; Widhalm, Kurt; Molnár, D.; Sjöström, Michael; González-Gross, Marcela; Ruiz, Jonatan R.

In: International Journal of Pediatric Obesity, Vol. 6, No. 3-4, 08.2011, p. 253-260.

Research output: Contribution to journalArticle

Jiménez-Pavón, D, Castillo, MJ, Moreno, LA, Kafatos, A, Manios, Y, Kondaki, K, Béghin, L, Zaccaria, M, De Henauw, S, Widhalm, K, Molnár, D, Sjöström, M, González-Gross, M & Ruiz, JR 2011, 'Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study', International Journal of Pediatric Obesity, vol. 6, no. 3-4, pp. 253-260. https://doi.org/10.3109/17477166.2011.575158
Jiménez-Pavón, David ; Castillo, Manuel J. ; Moreno, Luis A. ; Kafatos, Anthony ; Manios, Yannis ; Kondaki, Katerine ; Béghin, Laurent ; Zaccaria, Maria ; De Henauw, Stefaan ; Widhalm, Kurt ; Molnár, D. ; Sjöström, Michael ; González-Gross, Marcela ; Ruiz, Jonatan R. / Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study. In: International Journal of Pediatric Obesity. 2011 ; Vol. 6, No. 3-4. pp. 253-260.
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AU - Jiménez-Pavón, David

AU - Castillo, Manuel J.

AU - Moreno, Luis A.

AU - Kafatos, Anthony

AU - Manios, Yannis

AU - Kondaki, Katerine

AU - Béghin, Laurent

AU - Zaccaria, Maria

AU - De Henauw, Stefaan

AU - Widhalm, Kurt

AU - Molnár, D.

AU - Sjöström, Michael

AU - González-Gross, Marcela

AU - Ruiz, Jonatan R.

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N2 - Objective. To examine the independent association of total and central body fat and cardiorespiratory fitness with markers of insulin resistance after controlling for several potential confounders in European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional) study. Methods. We conducted a cross sectional study (the HELENA-CSS) which comprised 1053 (12.517.5 years) adolescents from 10 European cities. Weight, height, waist circumference and skinfold thickness were measured, and body mass index (BMI) was calculated. Cardiorespiratory fitness was measured by the 20-m shuttle run test. Markers of insulin resistance were fasting insulin and glucose, and homeostasis model assessment (HOMA). Results. HOMA and insulin were positively associated with BMI, skinfolds and waist circumference after controlling for center, age, pubertal status and cardiorespiratory fitness (all P ≤ 0.01). HOMA and insulin were negatively associated with cardiorespiratory fitness in adolescents with moderate to high levels of total and central body fat (all P ≤ 0.01). Conclusions. HOMA and insulin were associated with total and central body fat in European adolescents. Moreover, cardiorespiratory fitness explained a part of the HOMA and insulin variance in those adolescents with moderate to high levels of total and central body fat, and also, to some extent, in those with low to middle fat mass.

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