FISH diagnosztika

Z. Sápi, Bodó Miklós

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

For over two decades banding has remained the 'gold standard' of cytogenetic analysis, providing the first genome-wide screen for abnormalities. However, conventional cytogenetic banding techniques are limited to the detection of rearrangements involving more than 2 Mb of DNA. In addition, the identification of de novo unbalanced chromosome rearrangements provides a particular challenge for chromosome banding to decipher. In recent years a number of techniques based on FISH have evolved, all of which complement the conventional banding approaches and which have steadily increased the accuracy of cytogenetic diagnosis. FISH is now the method of choice because of the increased sensitivity, and speed with which it can be applied to a variety of cellular targets. In this article we try to highlight the technical aspects of FISH and the practical application of this technique on different tumors (soft tissue tumors, breast carcinomas, renal cell carcinomas, bladder tumors and germ cell tumors).

Original languageHungarian
Pages (from-to)25-32
Number of pages8
JournalMagyar Onkologia
Volume46
Issue number1
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Oncology

Cite this

Sápi, Z., & Miklós, B. (2002). FISH diagnosztika. Magyar Onkologia, 46(1), 25-32.

FISH diagnosztika. / Sápi, Z.; Miklós, Bodó.

In: Magyar Onkologia, Vol. 46, No. 1, 2002, p. 25-32.

Research output: Contribution to journalArticle

Sápi, Z & Miklós, B 2002, 'FISH diagnosztika', Magyar Onkologia, vol. 46, no. 1, pp. 25-32.
Sápi Z, Miklós B. FISH diagnosztika. Magyar Onkologia. 2002;46(1):25-32.
Sápi, Z. ; Miklós, Bodó. / FISH diagnosztika. In: Magyar Onkologia. 2002 ; Vol. 46, No. 1. pp. 25-32.
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