First-trimester maternal serum PP13 in the risk assessment for preeclampsia

Roberto Romero, Juan Pedro Kusanovic, Nandor Gabor Than, Offer Erez, Francesca Gotsch, Jimmy Espinoza, Samuel Edwin, Ilana Chefetz, Ricardo Gomez, Jyh Kae Nien, Marei Sammar, Beth Pineles, Sonia S. Hassan, Hamutal Meiri, Yossi Tal, Ido Kuhnreich, Z. Papp, Howard S. Cuckle

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Objective: The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia. Study Design: This case-control study included 50 patients with preeclampsia and 250 patients with normal pregnancies. Samples were collected between 8 and 13 weeks of gestation. Serum PP13 concentrations were measured by immunoassay and expressed as medians and multiples of the median (MoM) for gestational age. Sensitivity and specificity were derived from receiver-operating characteristic curve analysis. Results: (1) Serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies; and (2) at 80% specificity, a cutoff of 0.39 MoM had a sensitivity of 100% for early-onset preeclampsia and 85% for preterm preeclampsia. Conclusion: Maternal serum first-trimester PP13 appears to be a reasonable marker for risk assessment for preterm preeclampsia but a weak marker for severe preeclampsia at term, and ineffective for identifying mild preeclampsia at term.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number2
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Pregnancy Proteins
First Pregnancy Trimester
Pre-Eclampsia
Blood Proteins
Mothers
Pregnancy
Immunoassay
ROC Curve
Gestational Age
Case-Control Studies
Sensitivity and Specificity

Keywords

  • high-risk pregnancy
  • maternal serum biochemistry
  • prenatal care
  • risk assessment
  • screening

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

Romero, R., Kusanovic, J. P., Than, N. G., Erez, O., Gotsch, F., Espinoza, J., ... Cuckle, H. S. (2008). First-trimester maternal serum PP13 in the risk assessment for preeclampsia. American Journal of Obstetrics and Gynecology, 199(2). https://doi.org/10.1016/j.ajog.2008.01.013

First-trimester maternal serum PP13 in the risk assessment for preeclampsia. / Romero, Roberto; Kusanovic, Juan Pedro; Than, Nandor Gabor; Erez, Offer; Gotsch, Francesca; Espinoza, Jimmy; Edwin, Samuel; Chefetz, Ilana; Gomez, Ricardo; Nien, Jyh Kae; Sammar, Marei; Pineles, Beth; Hassan, Sonia S.; Meiri, Hamutal; Tal, Yossi; Kuhnreich, Ido; Papp, Z.; Cuckle, Howard S.

In: American Journal of Obstetrics and Gynecology, Vol. 199, No. 2, 08.2008.

Research output: Contribution to journalArticle

Romero, R, Kusanovic, JP, Than, NG, Erez, O, Gotsch, F, Espinoza, J, Edwin, S, Chefetz, I, Gomez, R, Nien, JK, Sammar, M, Pineles, B, Hassan, SS, Meiri, H, Tal, Y, Kuhnreich, I, Papp, Z & Cuckle, HS 2008, 'First-trimester maternal serum PP13 in the risk assessment for preeclampsia', American Journal of Obstetrics and Gynecology, vol. 199, no. 2. https://doi.org/10.1016/j.ajog.2008.01.013
Romero, Roberto ; Kusanovic, Juan Pedro ; Than, Nandor Gabor ; Erez, Offer ; Gotsch, Francesca ; Espinoza, Jimmy ; Edwin, Samuel ; Chefetz, Ilana ; Gomez, Ricardo ; Nien, Jyh Kae ; Sammar, Marei ; Pineles, Beth ; Hassan, Sonia S. ; Meiri, Hamutal ; Tal, Yossi ; Kuhnreich, Ido ; Papp, Z. ; Cuckle, Howard S. / First-trimester maternal serum PP13 in the risk assessment for preeclampsia. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 199, No. 2.
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abstract = "Objective: The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia. Study Design: This case-control study included 50 patients with preeclampsia and 250 patients with normal pregnancies. Samples were collected between 8 and 13 weeks of gestation. Serum PP13 concentrations were measured by immunoassay and expressed as medians and multiples of the median (MoM) for gestational age. Sensitivity and specificity were derived from receiver-operating characteristic curve analysis. Results: (1) Serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies; and (2) at 80{\%} specificity, a cutoff of 0.39 MoM had a sensitivity of 100{\%} for early-onset preeclampsia and 85{\%} for preterm preeclampsia. Conclusion: Maternal serum first-trimester PP13 appears to be a reasonable marker for risk assessment for preterm preeclampsia but a weak marker for severe preeclampsia at term, and ineffective for identifying mild preeclampsia at term.",
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AU - Gotsch, Francesca

AU - Espinoza, Jimmy

AU - Edwin, Samuel

AU - Chefetz, Ilana

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AU - Pineles, Beth

AU - Hassan, Sonia S.

AU - Meiri, Hamutal

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AU - Papp, Z.

AU - Cuckle, Howard S.

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