First trimester diagnosis of cystic fibrosis with linked DNA probes.

M. Németi, Z. Papp

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In late 1985 the cystic fibrosis (CF) gene was located to chromosome 7, at 7q 22/31. Several restriction fragment length polymorphism (RFLP) markers are closely linked to the CF gene. These markers permit accurate first-trimester prenatal diagnosis based on analysis of chorionic villus DNA by studies of families with one or more affected children. In our laboratory 13 families at risk of having a child with CF have been counselled by the use of linked DNA probes: xV-2c; pCS.7; Met H; Met D; pJ3.11; KM 19. In all cases one or more of the mentioned probes were sufficiently informative to allow first-trimester prenatal diagnosis. In four of the 13 families tested prenatal diagnosis have been performed.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalActa Universitatis Carolinae Medica
Volume36
Issue number1-4
Publication statusPublished - 1990

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DNA Probes
First Pregnancy Trimester
Prenatal Diagnosis
Cystic Fibrosis
Chorionic Villi
Chromosomes, Human, Pair 7
Restriction Fragment Length Polymorphisms
Genes
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

First trimester diagnosis of cystic fibrosis with linked DNA probes. / Németi, M.; Papp, Z.

In: Acta Universitatis Carolinae Medica, Vol. 36, No. 1-4, 1990, p. 135-138.

Research output: Contribution to journalArticle

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