First phytochemical investigation of secondary metabolites of Euphorbia davidii Subils. and antiproliferative activity of its extracts short communication

D. Rédei, Norbert Kúsz, Máté Szabó, Gyula Pinke, I. Zupkó, J. Hohmann

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaempferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
JournalActa Biologica Hungarica
Volume66
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Euphorbia
Plant Extracts
secondary metabolite
Phytochemicals
Cell growth
Glycosides
Chloroform
Metabolites
Flavonoids
Methanol
Assays
Skin
Adenocarcinoma
Cells
communication
Communication
chloroform
Cervix Uteri
methanol
Squamous Cell Carcinoma

Keywords

  • Antiproliferative activity
  • Euphorbia davidii
  • Flavonoid glycoside

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

First phytochemical investigation of secondary metabolites of Euphorbia davidii Subils. and antiproliferative activity of its extracts short communication. / Rédei, D.; Kúsz, Norbert; Szabó, Máté; Pinke, Gyula; Zupkó, I.; Hohmann, J.

In: Acta Biologica Hungarica, Vol. 66, No. 4, 01.12.2015, p. 464-467.

Research output: Contribution to journalArticle

@article{26308dca978f4b29ba74c38aa4467ec6,
title = "First phytochemical investigation of secondary metabolites of Euphorbia davidii Subils. and antiproliferative activity of its extracts short communication",
abstract = "The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaempferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.",
keywords = "Antiproliferative activity, Euphorbia davidii, Flavonoid glycoside",
author = "D. R{\'e}dei and Norbert K{\'u}sz and M{\'a}t{\'e} Szab{\'o} and Gyula Pinke and I. Zupk{\'o} and J. Hohmann",
year = "2015",
month = "12",
day = "1",
doi = "10.1556/018.66.2015.4.11",
language = "English",
volume = "66",
pages = "464--467",
journal = "Acta Biologica Hungarica",
issn = "0236-5383",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - First phytochemical investigation of secondary metabolites of Euphorbia davidii Subils. and antiproliferative activity of its extracts short communication

AU - Rédei, D.

AU - Kúsz, Norbert

AU - Szabó, Máté

AU - Pinke, Gyula

AU - Zupkó, I.

AU - Hohmann, J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaempferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.

AB - The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaempferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.

KW - Antiproliferative activity

KW - Euphorbia davidii

KW - Flavonoid glycoside

UR - http://www.scopus.com/inward/record.url?scp=84948686915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948686915&partnerID=8YFLogxK

U2 - 10.1556/018.66.2015.4.11

DO - 10.1556/018.66.2015.4.11

M3 - Article

C2 - 26616378

AN - SCOPUS:84948686915

VL - 66

SP - 464

EP - 467

JO - Acta Biologica Hungarica

JF - Acta Biologica Hungarica

SN - 0236-5383

IS - 4

ER -