First glance at the plant APC/C, a highly conserved ubiquitin-protein ligase

Arnaud Capron, L. Ökrész, Pascal Genschik

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The anaphase-promoting complex or cyclosome (APC/C) is a cell-cycle-regulated ubiquitin-protein ligase that has been extensively studied in both fungal and animal cells. Many APC/C protein targets have been identified, and their sequential degradation during the cell cycle is essential for chromatid separation and mitotic exit. APC/C-dependent ubiquitylation of proteins not involved in cell-cycle progression has also been documented in animal cells. By contrast, the plant APC/C's structure and functions remained unexplored until recently. Here, we discuss recent developments in this field and explore the Arabidopsis genome sequence to identify plant APC/C components. Details of the APC/C ubiquitylation pathway in Arabidopsis are also available on a website that will be regularly updated.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalTrends in Plant Science
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

Fingerprint

Anaphase-Promoting Complex-Cyclosome
ubiquitin-protein ligase
Ubiquitin-Protein Ligases
cell cycle
Cell Cycle
Ubiquitination
Arabidopsis
Chromatids
chromatids
animals
Proteins
proteins
anaphase promoting complex
Genome
cells
genome
degradation

ASJC Scopus subject areas

  • Genetics

Cite this

First glance at the plant APC/C, a highly conserved ubiquitin-protein ligase. / Capron, Arnaud; Ökrész, L.; Genschik, Pascal.

In: Trends in Plant Science, Vol. 8, No. 2, 01.02.2003, p. 83-89.

Research output: Contribution to journalArticle

Capron, Arnaud ; Ökrész, L. ; Genschik, Pascal. / First glance at the plant APC/C, a highly conserved ubiquitin-protein ligase. In: Trends in Plant Science. 2003 ; Vol. 8, No. 2. pp. 83-89.
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