First Cross-Coupling Reactions on Tetrazines

Zoltán Novák, András Kotschy

Research output: Contribution to journalArticle

50 Citations (Scopus)


Equation presented. A series of substituted chlorotetrazines were reacted with different terminal alkynes under Sonogashira or Negishi coupling conditions to furnish alkynyl-tetrazines in good to moderate yield. The electron-donating properties of the substituent on the tetrazine core were found to have a significant influence on the success of the reaction. These results constitute the first cross-coupling reactions on tetrazines.

Original languageEnglish
Pages (from-to)3495-3497
Number of pages3
JournalOrganic Letters
Issue number19
Publication statusPublished - Sep 18 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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