First Cross-Coupling Reactions on Tetrazines

Z. Novák, András Kotschy

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Equation presented. A series of substituted chlorotetrazines were reacted with different terminal alkynes under Sonogashira or Negishi coupling conditions to furnish alkynyl-tetrazines in good to moderate yield. The electron-donating properties of the substituent on the tetrazine core were found to have a significant influence on the success of the reaction. These results constitute the first cross-coupling reactions on tetrazines.

Original languageEnglish
Pages (from-to)3495-3497
Number of pages3
JournalOrganic Letters
Volume5
Issue number19
DOIs
Publication statusPublished - Sep 18 2003

Fingerprint

Alkynes
cross coupling
Cross Reactions
Electrons
alkynes
electrons

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

First Cross-Coupling Reactions on Tetrazines. / Novák, Z.; Kotschy, András.

In: Organic Letters, Vol. 5, No. 19, 18.09.2003, p. 3495-3497.

Research output: Contribution to journalArticle

Novák, Z. ; Kotschy, András. / First Cross-Coupling Reactions on Tetrazines. In: Organic Letters. 2003 ; Vol. 5, No. 19. pp. 3495-3497.
@article{1a6db3d292d145d99630d902b3f09001,
title = "First Cross-Coupling Reactions on Tetrazines",
abstract = "Equation presented. A series of substituted chlorotetrazines were reacted with different terminal alkynes under Sonogashira or Negishi coupling conditions to furnish alkynyl-tetrazines in good to moderate yield. The electron-donating properties of the substituent on the tetrazine core were found to have a significant influence on the success of the reaction. These results constitute the first cross-coupling reactions on tetrazines.",
author = "Z. Nov{\'a}k and Andr{\'a}s Kotschy",
year = "2003",
month = "9",
day = "18",
doi = "10.1021/ol035312w",
language = "English",
volume = "5",
pages = "3495--3497",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",

}

TY - JOUR

T1 - First Cross-Coupling Reactions on Tetrazines

AU - Novák, Z.

AU - Kotschy, András

PY - 2003/9/18

Y1 - 2003/9/18

N2 - Equation presented. A series of substituted chlorotetrazines were reacted with different terminal alkynes under Sonogashira or Negishi coupling conditions to furnish alkynyl-tetrazines in good to moderate yield. The electron-donating properties of the substituent on the tetrazine core were found to have a significant influence on the success of the reaction. These results constitute the first cross-coupling reactions on tetrazines.

AB - Equation presented. A series of substituted chlorotetrazines were reacted with different terminal alkynes under Sonogashira or Negishi coupling conditions to furnish alkynyl-tetrazines in good to moderate yield. The electron-donating properties of the substituent on the tetrazine core were found to have a significant influence on the success of the reaction. These results constitute the first cross-coupling reactions on tetrazines.

UR - http://www.scopus.com/inward/record.url?scp=0344392779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344392779&partnerID=8YFLogxK

U2 - 10.1021/ol035312w

DO - 10.1021/ol035312w

M3 - Article

VL - 5

SP - 3495

EP - 3497

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 19

ER -