Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience

H. Hirase, X. Leinekugel, A. Czurkó, J. Csicsvari, G. Buzsáki

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-sleep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered.

Original languageEnglish
Pages (from-to)9386-9390
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number16
DOIs
Publication statusPublished - Jul 31 2001

ASJC Scopus subject areas

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