Fine-tuning of helper T cell activation and apoptosis by antigen-presenting cells

Katalin Ludanyi, Peter Gogolak, Bence Rethi, Maria Magocsi, Cynthia Detre, Janos Matko, Eva Rajnavolgyi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The role of antigen-presenting cells (APC) in regulating helper T cell responses and activation-induced cell death (AICD) was investigated in vitro. T cell activation was monitored by measuring the early rise of intracellular free calcium [Ca+]ic, mRNA and cell surface expression of activation and apoptotic molecules, the production of cytokines and the activation of transcription factors. Our results demonstrate that the unique characteristics of a given APC can modify the threshold, kinetics and magnitude of the T cell response. The rapid and sustained rise of intracellular free calcium correlated well with the extent of cytokine production and the expression of activation molecules. Fas-dependent AICD could be induced by the most potent antigen-presenting cell (2PK3) only. Our results demonstrate that the response and fate of effector/memory CD4+ helper T lymphocytes is highly dependent on the individual properties of the APC they encounter.

Original languageEnglish
Pages (from-to)939-950
Number of pages12
JournalCellular Signalling
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 1 2004

Keywords

  • AICD
  • APC
  • Antigen presentation
  • Antigen-specific activation
  • Co-stimulation
  • Helper T cell
  • T cell signaling
  • TCR

ASJC Scopus subject areas

  • Cell Biology

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