Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D

B. Dietzschold, R. J. Eisenberg, M. Ponce de Leon, E. Golub, F. Hudecz, A. Varrichio, G. H. Cohen

Research output: Contribution to journalArticle

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Abstract

The fine structure of the antigenic determinants of herpes simplex virus type 1 and 2 glycoprotein D (gD) was analyzed to determine whether structural differences underlie the differential immunogenicity of these glycoproteins. A region common to herpes simplex virus type 1 and 2 gD (amino acid residues 11 to 19) and two sites specific for herpes simplex virus type 2 gD (one determined by proline at position 7, the other determined by asparagine at position 21) were localized within the N-terminal 23 amino acids of gD by synthesis of peptides and comparison of their cross-reactivity with antisera raised to herpes simplex virus type 1 and 2 gD. The secondary structure of these peptides, as predicted by computer analysis, is discussed in relation to their immunogenicity.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalJournal of Virology
Volume52
Issue number2
Publication statusPublished - 1984

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herpes simplex
Human Herpesvirus 2
Simplexvirus
Human herpesvirus 2
glycoproteins
Glycoproteins
Human Herpesvirus 1
Human herpesvirus 1
viruses
Amino Acids
Peptides
Asparagine
Proline
immune response
peptides
computer analysis
Immune Sera
Epitopes
amino acids
asparagine

ASJC Scopus subject areas

  • Immunology

Cite this

Dietzschold, B., Eisenberg, R. J., Ponce de Leon, M., Golub, E., Hudecz, F., Varrichio, A., & Cohen, G. H. (1984). Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D. Journal of Virology, 52(2), 431-435.

Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D. / Dietzschold, B.; Eisenberg, R. J.; Ponce de Leon, M.; Golub, E.; Hudecz, F.; Varrichio, A.; Cohen, G. H.

In: Journal of Virology, Vol. 52, No. 2, 1984, p. 431-435.

Research output: Contribution to journalArticle

Dietzschold, B, Eisenberg, RJ, Ponce de Leon, M, Golub, E, Hudecz, F, Varrichio, A & Cohen, GH 1984, 'Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D', Journal of Virology, vol. 52, no. 2, pp. 431-435.
Dietzschold B, Eisenberg RJ, Ponce de Leon M, Golub E, Hudecz F, Varrichio A et al. Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D. Journal of Virology. 1984;52(2):431-435.
Dietzschold, B. ; Eisenberg, R. J. ; Ponce de Leon, M. ; Golub, E. ; Hudecz, F. ; Varrichio, A. ; Cohen, G. H. / Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D. In: Journal of Virology. 1984 ; Vol. 52, No. 2. pp. 431-435.
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