Fine structural studies in myasthenia gravis

II. lesions of the neuromuscular junction

A. Korényi-Both, Albert Szobor, K. Lapis, I. Szathmáry

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Electron microscopic studies were performed on muscle biopsy samples from 23 myasthenic patients. The fine structural changes in the neuromuscular junctions found in 7 of these cases, have been investigated. Deformations and hyperplasy of the post-synaptic apparatus were observed, as well as a reduction, or occasionally a considerable increase, in the number of postsynaptic folds. The synaptic gap was dilated at times. Increases in the amount of the basement membrane material were also recorded. The retraction of the terminal axon was seen in advanced cases. It is suggested that the alterations of the synaptic gap may hinder or block diffusion of acetylcholine to the post-synaptic receptors. The fine structural changes lead morphologically in a very advanced stage to development of ‘intersynaptic denervation’ in the neuromuscular space. On the basis of their observations, the authors claim that in some myasthenia gravis cases there may be a correlation between the suggested autoimmune mechanism and the fine structural alterations.

Original languageEnglish
Pages (from-to)311-323
Number of pages13
JournalEuropean Neurology
Volume10
Issue number5
DOIs
Publication statusPublished - 1973

Fingerprint

Neurotransmitter Receptor
Neuromuscular Junction
Myasthenia Gravis
Muscle Weakness
Presynaptic Terminals
Denervation
Basement Membrane
Acetylcholine
Electrons
Biopsy
Muscles

Keywords

  • Denervation
  • Electron microscopy
  • End-plate
  • Intersynaptic
  • Myasthenia gravis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Fine structural studies in myasthenia gravis : II. lesions of the neuromuscular junction. / Korényi-Both, A.; Szobor, Albert; Lapis, K.; Szathmáry, I.

In: European Neurology, Vol. 10, No. 5, 1973, p. 311-323.

Research output: Contribution to journalArticle

Korényi-Both, A. ; Szobor, Albert ; Lapis, K. ; Szathmáry, I. / Fine structural studies in myasthenia gravis : II. lesions of the neuromuscular junction. In: European Neurology. 1973 ; Vol. 10, No. 5. pp. 311-323.
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