Cytotoxic T lymphocytes (CTL) were generated to syngeneic cells derivatized with serologically cross‐reactive compounds (4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) and (4‐hydroxy‐5‐iodo‐3‐nitro‐phenyl)acetyl (NIP) in order to investigate the possible role of a heteroclytic T and B cell receptor marker (U. Krawinkel et al., Eur. J. Immunol. 1977. 7: 566) in CTL‐target cell interaction. The cytotoxic cells of both BALB/c and C57BL/10 (B 10) origin react specifically with target cells of the inducer type; no heteroclicity of the overall cytotoxic response can be observed by CTL of B 10 origin. The results suggest that in this system, the specificity of CTL is determined by a receptor with a variable region different from that of the isolated NP‐specific antigen‐ binding T cell receptor material.
ASJC Scopus subject areas
- Immunology and Allergy