Film coating as a new approach to prepare tablets containing long-term stable Lactobacillus acidophilus

István Wagner, Zsombor Kristóf Nagy, ÁGnes Suhajda, Hajnalka Pataki, Péter Sóti, Tamás Vigh, Attila Balogh, Anna Helga Haraszto, G. Marosi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This work presents a study of film coating with the vaginal strain of Lactobacillus acidophilus, the aim of which was to dry the bacteria and manufacture probiotic tablets in one step and to enhance the survival rate of bacteria and their viability during storage. The results show that the film coated lactose-based tablets contained viable bacteria and the survival rate after the process was 21 %, which could be enhanced up to 59 % by applying protective media (trehalose, sucrose, reconstituted skim milk (RSM)) during dehydration. Additionally, protective agents improved the viability of bacteria during storage too. After one year, 20 % of the embedded bacteria were active when stored at –20°C, and viability dropped only one order of magnitude when stored at 7°C. It was verified that the bacteria in film coated tablets were not sensitive to higher levels of humidity owing to the moisture-moderating polyvinyl alcohol-based coating composite. The described technology for production of tablets containing living bacteria by tablet coating seems industrially feasible as tablet film coaters are widespread in the pharmaceutical industry.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalPeriodica Polytechnica: Chemical Engineering
Volume59
Issue number1
Publication statusPublished - 2015

Fingerprint

Tablets
Bacteria
Coatings
Polyvinyl Alcohol
Protective Agents
Trehalose
Composite coatings
Polyvinyl alcohols
Sugar (sucrose)
Lactose
Dehydration
Drug products
Sucrose
Atmospheric humidity
Moisture
Pharmaceutical Preparations
Industry

Keywords

  • Bacterialis vaginosis
  • Film coating
  • Lactobacillus acidophilus
  • Probiotics
  • Stability
  • Vaginal tablet

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Film coating as a new approach to prepare tablets containing long-term stable Lactobacillus acidophilus. / Wagner, István; Nagy, Zsombor Kristóf; Suhajda, ÁGnes; Pataki, Hajnalka; Sóti, Péter; Vigh, Tamás; Balogh, Attila; Haraszto, Anna Helga; Marosi, G.

In: Periodica Polytechnica: Chemical Engineering, Vol. 59, No. 1, 2015, p. 96-103.

Research output: Contribution to journalArticle

Wagner, I, Nagy, ZK, Suhajda, ÁG, Pataki, H, Sóti, P, Vigh, T, Balogh, A, Haraszto, AH & Marosi, G 2015, 'Film coating as a new approach to prepare tablets containing long-term stable Lactobacillus acidophilus', Periodica Polytechnica: Chemical Engineering, vol. 59, no. 1, pp. 96-103.
Wagner, István ; Nagy, Zsombor Kristóf ; Suhajda, ÁGnes ; Pataki, Hajnalka ; Sóti, Péter ; Vigh, Tamás ; Balogh, Attila ; Haraszto, Anna Helga ; Marosi, G. / Film coating as a new approach to prepare tablets containing long-term stable Lactobacillus acidophilus. In: Periodica Polytechnica: Chemical Engineering. 2015 ; Vol. 59, No. 1. pp. 96-103.
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