Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis.

B. Nagy, E. Katona, J. Erdei, L. Máródi, E. Székely, T. Márialigeti, L. Karmazsin, J. Fachet

Research output: Contribution to journalArticle

Abstract

Fibronectin is normally present in the lower respiratory tract. Significantly increased levels of it were detected in the lavage fluid in patients with interstitial lung diseases. Because this molecule appears to mediate a number of components of the inflammatory process, we evaluated the status of fibronectin in plasma and bronchoalveolar lavage in patients with recurrent obstructive bronchitis when signs of severe chronic mucosal inflammation were observed bronchoscopically. There was no considerable difference in plasma concentrations of fibronectin obtained from healthy children and patients. A comparison of lavage fibronectin/albumin ratios with plasma fibronectin/albumin ratios suggested significant local production, especially when the lavage and plasma ratios were measured in the same patients. Phagocytic activity of alveolar macrophages and blood granulocytes from the same patients was enhanced at both concentrations of fibronectin used. This concentrations referred to values quantified in the lavage fluid. The metabolism of fibronectin seems to be an important factor in tracing the inflammation process not only in adults with chronic interstitial lung diseases, but also in children with recurrent obstructive bronchitis.

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalActa Paediatrica Hungarica
Volume29
Issue number3-4
Publication statusPublished - 1988

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Bronchitis
Fibronectins
Therapeutic Irrigation
Interstitial Lung Diseases
Inflammation
Alveolar Macrophages
Bronchoalveolar Lavage
Granulocytes
Serum Albumin
Respiratory System
Albumins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nagy, B., Katona, E., Erdei, J., Máródi, L., Székely, E., Márialigeti, T., ... Fachet, J. (1988). Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis. Acta Paediatrica Hungarica, 29(3-4), 261-269.

Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis. / Nagy, B.; Katona, E.; Erdei, J.; Máródi, L.; Székely, E.; Márialigeti, T.; Karmazsin, L.; Fachet, J.

In: Acta Paediatrica Hungarica, Vol. 29, No. 3-4, 1988, p. 261-269.

Research output: Contribution to journalArticle

Nagy, B, Katona, E, Erdei, J, Máródi, L, Székely, E, Márialigeti, T, Karmazsin, L & Fachet, J 1988, 'Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis.', Acta Paediatrica Hungarica, vol. 29, no. 3-4, pp. 261-269.
Nagy, B. ; Katona, E. ; Erdei, J. ; Máródi, L. ; Székely, E. ; Márialigeti, T. ; Karmazsin, L. ; Fachet, J. / Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis. In: Acta Paediatrica Hungarica. 1988 ; Vol. 29, No. 3-4. pp. 261-269.
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