Fetomaternal transfusion and pregnancy outcome after cordocentesis

János Sikovanyecz, Emese Horváth, Éva Sallay, János Gellén, A. Pál, János Szabó

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To study the extent of fetomaternal transfusion and the outcome of pregnancy after cordocentesis. Material and Methods: 268 women underwent percutaneous fetal umbilical cord blood sampling for fetal karyo-typing between 15 and 26 gestations of weeks. Complete follow-up was available in 221 (82.5%) of the cases. Cordocentesis was performed under continuous real-time ultrasound guidance. The duration of the procedure and the post-procedural bleeding time was counted in seconds. Fetomaternal transfusion was calculated by using the measurements of the maternal serum levels of α-fetoprotein before and after the procedure. The data were analyzed by Student's t and multiple regression tests. Results: The maximum and mean amounts of fetomaternal transfusion were 1.067 and 0.061 ml, respectively. Twenty percent or more α-fetoprotein elevation was in 35.4% of the cases. Positive correlation was found between bleeding time after cordocentesis and fetomaternal transfusion (r = 0.174, p <0.0129) as well as between the duration of the procedure (r = 0.165, p <0.0171) and the amount of fetomaternal transfusion. Comparing the cordocentesis at the placental insertion site and at the free cord loop, a smaller amount of fetomaternal transfusion was observed (p <0.0123) in the latter. Transplacental passage was associated with a higher amount of fetomaternal transfusion (p <0.0067). No association was found between the extent of fetomaternal transfusion and the outcome of pregnancy. The fetal loss related to the cordocentesis was 0.50%. Conclusions: The extent of fetomaternal transfusion was influenced by the subsequent four parameters: procedural time, bleeding time, puncture site and transplacental penetration. The lack of the association between the degree of fetomaternal transfusion and the outcome of pregnancy, along with the low (0.50%) post-procedural fetal loss rate, suggest that cordocentesis is clinically a safe procedure.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalFetal Diagnosis and Therapy
Volume16
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Fetomaternal Transfusion
Cordocentesis
Pregnancy Outcome
Bleeding Time
Fetal Proteins
Fetal Blood
Punctures

Keywords

  • Cordocentesis
  • Fetomaternal transfusion
  • Pregnancy outcome
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Sikovanyecz, J., Horváth, E., Sallay, É., Gellén, J., Pál, A., & Szabó, J. (2001). Fetomaternal transfusion and pregnancy outcome after cordocentesis. Fetal Diagnosis and Therapy, 16(2), 83-89. https://doi.org/10.1159/000053886

Fetomaternal transfusion and pregnancy outcome after cordocentesis. / Sikovanyecz, János; Horváth, Emese; Sallay, Éva; Gellén, János; Pál, A.; Szabó, János.

In: Fetal Diagnosis and Therapy, Vol. 16, No. 2, 2001, p. 83-89.

Research output: Contribution to journalArticle

Sikovanyecz, J, Horváth, E, Sallay, É, Gellén, J, Pál, A & Szabó, J 2001, 'Fetomaternal transfusion and pregnancy outcome after cordocentesis', Fetal Diagnosis and Therapy, vol. 16, no. 2, pp. 83-89. https://doi.org/10.1159/000053886
Sikovanyecz, János ; Horváth, Emese ; Sallay, Éva ; Gellén, János ; Pál, A. ; Szabó, János. / Fetomaternal transfusion and pregnancy outcome after cordocentesis. In: Fetal Diagnosis and Therapy. 2001 ; Vol. 16, No. 2. pp. 83-89.
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abstract = "Objective: To study the extent of fetomaternal transfusion and the outcome of pregnancy after cordocentesis. Material and Methods: 268 women underwent percutaneous fetal umbilical cord blood sampling for fetal karyo-typing between 15 and 26 gestations of weeks. Complete follow-up was available in 221 (82.5{\%}) of the cases. Cordocentesis was performed under continuous real-time ultrasound guidance. The duration of the procedure and the post-procedural bleeding time was counted in seconds. Fetomaternal transfusion was calculated by using the measurements of the maternal serum levels of α-fetoprotein before and after the procedure. The data were analyzed by Student's t and multiple regression tests. Results: The maximum and mean amounts of fetomaternal transfusion were 1.067 and 0.061 ml, respectively. Twenty percent or more α-fetoprotein elevation was in 35.4{\%} of the cases. Positive correlation was found between bleeding time after cordocentesis and fetomaternal transfusion (r = 0.174, p <0.0129) as well as between the duration of the procedure (r = 0.165, p <0.0171) and the amount of fetomaternal transfusion. Comparing the cordocentesis at the placental insertion site and at the free cord loop, a smaller amount of fetomaternal transfusion was observed (p <0.0123) in the latter. Transplacental passage was associated with a higher amount of fetomaternal transfusion (p <0.0067). No association was found between the extent of fetomaternal transfusion and the outcome of pregnancy. The fetal loss related to the cordocentesis was 0.50{\%}. Conclusions: The extent of fetomaternal transfusion was influenced by the subsequent four parameters: procedural time, bleeding time, puncture site and transplacental penetration. The lack of the association between the degree of fetomaternal transfusion and the outcome of pregnancy, along with the low (0.50{\%}) post-procedural fetal loss rate, suggest that cordocentesis is clinically a safe procedure.",
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