Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Aquaporin-1 and aquaporin-4, water channel membrane proteins reported in both experimental animals and in adult humans, have been detected in different, non-overlapping areas of the central nervous system. This immunohistochemical study describes the developmental expression pattern of the water channel membrane proteins, aquaporin-1 and aquaporin-4, in various structures of human fetal brain over the gestational period of 14-40 weeks. Aquaporin-1 immunostaining was exclusively found in the epithelial cells of the choroid plexus from the 14th gestational week, and the staining pattern altered slightly over time. At week 14, immunostaining appeared only in the apical cell membranes. By the 18th gestational week, the entire plasma membrane of these apical cells was immunopositive, as well as was the cytosol. These changes in immunoreactivity indicate an increasing production of aquaporin-1 in the epithelial cells during the period between the 14th and 24th weeks of gestation. Aquaporin-4 immunostaining was first detected in the archicortex, from gestational week 14 and was detected in the neocortex, 6-7 weeks later. Immunostained structures were always astrocytes, particularly the astrocytic endfeet in the ventricular wall, at the developing ependymal lining, at the pial surface, and around the capillaries. Neuronal labeling was not observed. These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain.

Original languageEnglish
Pages (from-to)295-305
Number of pages11
JournalInternational Journal of Developmental Neuroscience
Volume24
Issue number5
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Aquaporin 1
Aquaporin 4
Extraembryonic Membranes
Aquaporins
Fetal Development
Ion Channels
Membrane Proteins
Brain
Epithelial Cells
Cell Membrane
Choroid Plexus
Neocortex
Astrocytes
Cytosol
Fetus
Homeostasis
Central Nervous System
Staining and Labeling
Pregnancy
Water

Keywords

  • Aquaporins
  • Brain development
  • Cerebrospinal fluid
  • Choroid plexus

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

@article{dc7bae4e9eca494895ec99e34f56c59c,
title = "Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain",
abstract = "Aquaporin-1 and aquaporin-4, water channel membrane proteins reported in both experimental animals and in adult humans, have been detected in different, non-overlapping areas of the central nervous system. This immunohistochemical study describes the developmental expression pattern of the water channel membrane proteins, aquaporin-1 and aquaporin-4, in various structures of human fetal brain over the gestational period of 14-40 weeks. Aquaporin-1 immunostaining was exclusively found in the epithelial cells of the choroid plexus from the 14th gestational week, and the staining pattern altered slightly over time. At week 14, immunostaining appeared only in the apical cell membranes. By the 18th gestational week, the entire plasma membrane of these apical cells was immunopositive, as well as was the cytosol. These changes in immunoreactivity indicate an increasing production of aquaporin-1 in the epithelial cells during the period between the 14th and 24th weeks of gestation. Aquaporin-4 immunostaining was first detected in the archicortex, from gestational week 14 and was detected in the neocortex, 6-7 weeks later. Immunostained structures were always astrocytes, particularly the astrocytic endfeet in the ventricular wall, at the developing ependymal lining, at the pial surface, and around the capillaries. Neuronal labeling was not observed. These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain.",
keywords = "Aquaporins, Brain development, Cerebrospinal fluid, Choroid plexus",
author = "E. G{\"o}m{\"o}ri and J. P{\'a}l and H. {\'A}brah{\'a}m and Z. Vajda and E. Sulyok and L. S{\'e}ress and T. D{\'o}czi",
year = "2006",
month = "8",
doi = "10.1016/j.ijdevneu.2006.05.003",
language = "English",
volume = "24",
pages = "295--305",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain

AU - Gömöri, E.

AU - Pál, J.

AU - Ábrahám, H.

AU - Vajda, Z.

AU - Sulyok, E.

AU - Séress, L.

AU - Dóczi, T.

PY - 2006/8

Y1 - 2006/8

N2 - Aquaporin-1 and aquaporin-4, water channel membrane proteins reported in both experimental animals and in adult humans, have been detected in different, non-overlapping areas of the central nervous system. This immunohistochemical study describes the developmental expression pattern of the water channel membrane proteins, aquaporin-1 and aquaporin-4, in various structures of human fetal brain over the gestational period of 14-40 weeks. Aquaporin-1 immunostaining was exclusively found in the epithelial cells of the choroid plexus from the 14th gestational week, and the staining pattern altered slightly over time. At week 14, immunostaining appeared only in the apical cell membranes. By the 18th gestational week, the entire plasma membrane of these apical cells was immunopositive, as well as was the cytosol. These changes in immunoreactivity indicate an increasing production of aquaporin-1 in the epithelial cells during the period between the 14th and 24th weeks of gestation. Aquaporin-4 immunostaining was first detected in the archicortex, from gestational week 14 and was detected in the neocortex, 6-7 weeks later. Immunostained structures were always astrocytes, particularly the astrocytic endfeet in the ventricular wall, at the developing ependymal lining, at the pial surface, and around the capillaries. Neuronal labeling was not observed. These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain.

AB - Aquaporin-1 and aquaporin-4, water channel membrane proteins reported in both experimental animals and in adult humans, have been detected in different, non-overlapping areas of the central nervous system. This immunohistochemical study describes the developmental expression pattern of the water channel membrane proteins, aquaporin-1 and aquaporin-4, in various structures of human fetal brain over the gestational period of 14-40 weeks. Aquaporin-1 immunostaining was exclusively found in the epithelial cells of the choroid plexus from the 14th gestational week, and the staining pattern altered slightly over time. At week 14, immunostaining appeared only in the apical cell membranes. By the 18th gestational week, the entire plasma membrane of these apical cells was immunopositive, as well as was the cytosol. These changes in immunoreactivity indicate an increasing production of aquaporin-1 in the epithelial cells during the period between the 14th and 24th weeks of gestation. Aquaporin-4 immunostaining was first detected in the archicortex, from gestational week 14 and was detected in the neocortex, 6-7 weeks later. Immunostained structures were always astrocytes, particularly the astrocytic endfeet in the ventricular wall, at the developing ependymal lining, at the pial surface, and around the capillaries. Neuronal labeling was not observed. These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain.

KW - Aquaporins

KW - Brain development

KW - Cerebrospinal fluid

KW - Choroid plexus

UR - http://www.scopus.com/inward/record.url?scp=33745684778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745684778&partnerID=8YFLogxK

U2 - 10.1016/j.ijdevneu.2006.05.003

DO - 10.1016/j.ijdevneu.2006.05.003

M3 - Article

C2 - 16814974

AN - SCOPUS:33745684778

VL - 24

SP - 295

EP - 305

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

IS - 5

ER -