Ferritin in kidney and vascular related diseases

Novel roles for an old player

J. Balla, G. Balla, Abolfazl Zarjou

Research output: Contribution to journalArticle

Abstract

Iron is at the forefront of a number of pivotal biological processes due to its ability to readily accept and donate electrons. However, this property may also catalyze the generation of free radicals with ensuing cellular and tissue toxicity. Accordingly, throughout evolution numerous pathways and proteins have evolved to minimize the potential hazardous effects of iron cations and yet allow for readily available iron cations in a wide variety of fundamental metabolic processes. One of the extensively studied proteins in the context of systemic and cellular iron metabolisms is ferritin. While clinicians utilize serum ferritin to monitor body iron stores and inflammation, it is important to note that the vast majority of ferritin is located intracellularly. Intracellular ferritin is made of two different subunits (heavy and light chain) and plays an imperative role as a safe iron depot. In the past couple of decades our understanding of ferritin biology has remarkably improved. Additionally, a significant body of evidence has emerged describing the significance of the kidney in iron trafficking and homeostasis. Here, we briefly discuss some of the most important findings that relate to the role of iron and ferritin heavy chain in the context of kidney-related diseases and, in particular, vascular calcification, which is a frequent complication of chronic kidney disease.

Original languageEnglish
Article number96
JournalPharmaceuticals
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 1 2019

Fingerprint

Ferritins
Vascular Diseases
Iron
Kidney
Cations
Apoferritins
Vascular Calcification
Biological Phenomena
Kidney Diseases
Chronic Renal Insufficiency
Free Radicals
Proteins
Homeostasis
Electrons
Inflammation
Light
Serum

Keywords

  • Acute kidney injury
  • Chronic kidney disease
  • Ferritin
  • Iron
  • Vascular calcification

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Ferritin in kidney and vascular related diseases : Novel roles for an old player. / Balla, J.; Balla, G.; Zarjou, Abolfazl.

In: Pharmaceuticals, Vol. 12, No. 2, 96, 01.06.2019.

Research output: Contribution to journalArticle

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