Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis

Andras Telekes, Akos Resetar, Geza Balint, Gabor Blazso, Gyorgy Falkay, Karoly Lapis, Erzsebet Raso, Bela Szende, Michael Ehrenfeld, Yehuda Shoenfeld, Mate Hidvegi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)


Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and antiinflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethasone were also given in combination. Besides plethysmographies of the paws, histological investigations of synovial tissues were also performed along with detection of CD4+ and CD8+ T lymphocytes. Gene expressions of COX-1 and 2 were determined by real-time polymerase chain reaction (PCR). FWGE monotherapy significantly inhibited the development of the secondary (immune-mediated) response in AA, and dexamethasone and indomethacin exerted inhibitory effects in a degree comparable to that of FWGE. Histological analysis of the affected joints confirmed the results. FWGE inhibited COX-1 and -2, while indomethacin enhanced COX-2 gene expressions. FWGE had an additive interaction with diclofenac. It is concluded that FWGE has significant anti-inflammatory efficacy confirmed by plethysmography, histology, and real-time PCR.

Original languageEnglish
Title of host publicationAutoimmunity, Part B Novel Applications of Basic Research
PublisherBlackwell Publishing Inc.
Number of pages14
ISBN (Print)1573317098, 9781573317092
Publication statusPublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632



  • Adjuvant arthritis
  • Anti-inflammatory effect
  • Avemar
  • COX-1 inhibition
  • COX-2 inhibition
  • FWGE
  • Fermented wheat germ extract

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Telekes, A., Resetar, A., Balint, G., Blazso, G., Falkay, G., Lapis, K., Raso, E., Szende, B., Ehrenfeld, M., Shoenfeld, Y., & Hidvegi, M. (2007). Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. In Autoimmunity, Part B Novel Applications of Basic Research (pp. 348-361). (Annals of the New York Academy of Sciences; Vol. 1110). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1423.037