Feline endotoxin shock

effects of methylprednisolone on kininogen depletion, on the pulmonary circulation and on survival

N. Al Kaisi, J. Parratt, H. H. Siddiqui, I. J. Zeitlin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Escherichia coli endotoxin, administered intravenously in a dose of 2 mg/kg to pentobarbitone-anesthetized, artificially ventilated cats resulted in pulmonary hypertension, systemic hypotension and an immediate (1-2 min) 30-40% reduction in plasma kininogen, an effect which probably indicates a release of plasma kinins. Methylprednisolone (30 mg/kg), when administered 30 min before endotoxin, did not influence the endotoxin-induced pulmonary hypertension or systemic hypotension but completely prevented the depletion of plasma kininogen. In spontaneously breathing cats, methylprednisolone, administered 30 min after endotoxin, caused a rapid repletion of kininogen and prolonged survival (47% at 6 hr compared to 10% in the endotoxin-alone animals). Methylprednisolone did not appear to influence lactate production or the hyperventilation observed during the delayed endotoxin shock phase. It is concluded that methylprednisolone does not prevent the release, by endotoxin, of a pulmonary vasoconstrictor prostaglandin, or its effects, but that perhaps by preventing kinin release it may reduce endotoxin-induced capillary leakage.

Original languageEnglish
Pages (from-to)47-476
Number of pages430
JournalBritish Journal of Pharmacology
Volume60
Issue number3
Publication statusPublished - 1977

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Kininogens
Pulmonary Circulation
Felidae
Methylprednisolone
Endotoxins
Shock
Kinins
Pulmonary Hypertension
Hypotension
Cats
Hyperventilation
Vasoconstrictor Agents
Pentobarbital
Prostaglandins
Lactic Acid
Respiration
Lung

ASJC Scopus subject areas

  • Pharmacology

Cite this

Feline endotoxin shock : effects of methylprednisolone on kininogen depletion, on the pulmonary circulation and on survival. / Al Kaisi, N.; Parratt, J.; Siddiqui, H. H.; Zeitlin, I. J.

In: British Journal of Pharmacology, Vol. 60, No. 3, 1977, p. 47-476.

Research output: Contribution to journalArticle

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abstract = "Escherichia coli endotoxin, administered intravenously in a dose of 2 mg/kg to pentobarbitone-anesthetized, artificially ventilated cats resulted in pulmonary hypertension, systemic hypotension and an immediate (1-2 min) 30-40{\%} reduction in plasma kininogen, an effect which probably indicates a release of plasma kinins. Methylprednisolone (30 mg/kg), when administered 30 min before endotoxin, did not influence the endotoxin-induced pulmonary hypertension or systemic hypotension but completely prevented the depletion of plasma kininogen. In spontaneously breathing cats, methylprednisolone, administered 30 min after endotoxin, caused a rapid repletion of kininogen and prolonged survival (47{\%} at 6 hr compared to 10{\%} in the endotoxin-alone animals). Methylprednisolone did not appear to influence lactate production or the hyperventilation observed during the delayed endotoxin shock phase. It is concluded that methylprednisolone does not prevent the release, by endotoxin, of a pulmonary vasoconstrictor prostaglandin, or its effects, but that perhaps by preventing kinin release it may reduce endotoxin-induced capillary leakage.",
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AU - Zeitlin, I. J.

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N2 - Escherichia coli endotoxin, administered intravenously in a dose of 2 mg/kg to pentobarbitone-anesthetized, artificially ventilated cats resulted in pulmonary hypertension, systemic hypotension and an immediate (1-2 min) 30-40% reduction in plasma kininogen, an effect which probably indicates a release of plasma kinins. Methylprednisolone (30 mg/kg), when administered 30 min before endotoxin, did not influence the endotoxin-induced pulmonary hypertension or systemic hypotension but completely prevented the depletion of plasma kininogen. In spontaneously breathing cats, methylprednisolone, administered 30 min after endotoxin, caused a rapid repletion of kininogen and prolonged survival (47% at 6 hr compared to 10% in the endotoxin-alone animals). Methylprednisolone did not appear to influence lactate production or the hyperventilation observed during the delayed endotoxin shock phase. It is concluded that methylprednisolone does not prevent the release, by endotoxin, of a pulmonary vasoconstrictor prostaglandin, or its effects, but that perhaps by preventing kinin release it may reduce endotoxin-induced capillary leakage.

AB - Escherichia coli endotoxin, administered intravenously in a dose of 2 mg/kg to pentobarbitone-anesthetized, artificially ventilated cats resulted in pulmonary hypertension, systemic hypotension and an immediate (1-2 min) 30-40% reduction in plasma kininogen, an effect which probably indicates a release of plasma kinins. Methylprednisolone (30 mg/kg), when administered 30 min before endotoxin, did not influence the endotoxin-induced pulmonary hypertension or systemic hypotension but completely prevented the depletion of plasma kininogen. In spontaneously breathing cats, methylprednisolone, administered 30 min after endotoxin, caused a rapid repletion of kininogen and prolonged survival (47% at 6 hr compared to 10% in the endotoxin-alone animals). Methylprednisolone did not appear to influence lactate production or the hyperventilation observed during the delayed endotoxin shock phase. It is concluded that methylprednisolone does not prevent the release, by endotoxin, of a pulmonary vasoconstrictor prostaglandin, or its effects, but that perhaps by preventing kinin release it may reduce endotoxin-induced capillary leakage.

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