Fehérje-szénhidrát kölcsönhatások

Research output: Contribution to journalArticle

Abstract

Protein-carbohydrate interactions Numerous reports describe the carbohydrate-mediated cell interactions. Carbohydrate binding proteins (lectins), glycosyltransferases, glycosidases, antibodies and toxins found at the cell surfaces interact with carbohydrate-type ligands. The ligand's specificity is determined by complex oligosaccharide structures. The present article describes the chemical synthesis of very different oligosaccharides which are the substrates of enzymes, or participate in the production of phytoalexins. New selectin ligands were also prepared providing the stable negative charge of Sialyl-Lewis X analogues. The O-specific polysaccharide (OPS) of the lipopolysaccharide of Shigella sonnei was studied and the synthesis of the disaccharide-type repeating unit was executed. The cell surface antigens of different mycobacteria present a very rich variety of complex oligosaccharides. These oligosaccharides contain rare sugars, unusual bond-types and different non-carbohydrate substitutes. New syntheses were worked out for the oligosaccharide antigens of M. leprae, M. avium serovars 8, 12, 14, 17 and 20. In the case of M. avium serovars 19 a very complex structure was verified by total synthesis. The unique step of this synthesis is the glycosylation of the tertiary hydroxil group of sugar moieties. The paper gives a broad overview on the role of synthesis in carbohydrate chemistry to provide samples for biological investigations.

Original languageHungarian
Pages (from-to)319-330
Number of pages12
JournalMagyar Kemiai Folyoirat, Kemiai Kozlemenyek
Volume106
Issue number8
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Fehérje-szénhidrát kölcsönhatások. / Lipták, A.

In: Magyar Kemiai Folyoirat, Kemiai Kozlemenyek, Vol. 106, No. 8, 2000, p. 319-330.

Research output: Contribution to journalArticle

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