Feeding-related dopamine in the amygdala of freely moving rats

András Hajnal, László Lénárd

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

EXTRACELLULAR levels of dopamine (DA) were measured in the central part (the central and intercalated nuclei) of the amygdala (AMY) using microdialysis at 20 min intervals before, during and after 1 h of feeding in 12 h food-deprived rats. The results were compared with the effects of peripheral injections of glucose or a low dose (200 mU) of insulin in non- deprived animals. Feeding caused a 130% increase in extracellular DA. Glucose resulted in an increase in DA levels (+86%). In contrast, insulin caused a decrease of DA (-50%) and metabolites. The results show that natural feeding is associated with an increase in DA turnover in the amygdala, and that peripheral glucose and insulin can affect DA metabolism in the amygdala presumably in response to changes in glucose utilization.

Original languageEnglish
Pages (from-to)2817-2820
Number of pages4
JournalNeuroreport
Volume8
Issue number12
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • Amygdala
  • Dopamine
  • Feeding
  • Glucose
  • Insulin
  • Microdialysis
  • Rats

ASJC Scopus subject areas

  • Neuroscience(all)

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