Feeding purified glycerol from biodiesel to CBA/CA mice: Effects on Gadd45a and Nfκb1 expressions

Szele Eszter, Gombos Katalin, Kovács András, Ember István

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The turn towards renewable energy sources has increased the production of biodiesel from rapeseed oil, leaving glycerol as a valuable by-product. Several studies have evaluated this product in feed for poultry, swine and ruminants. We investigated the effect of these glycerol products on the expression of DNA damage-inducible genes in mice. Materials and Methods: CBA/CA mice were administered two different purified glycerol products (SZME2, SZME3) for 3, 6 and 24 hours. After dietary exposure, gene expressions of nuclear factor kappa-light-chain-enhancer of activated B-cells 1 (NFkb1) and growth arrest and DNA-damage-inducible protein 45 alpha (Gadd45a) were analysed. Results: SZME2 induced a down-regulation of the two genes in all investigated organs, including the bone marrow in both genders. After administration of SZME3, up-regulation of the two genes was observed in bone marrow in males, and the up-regulation of Gadd45a in liver, also in males. Conclusion: Based upon our data, SZME3, which contains glycerol of higher purification, did not induce down-regulation in genes which are involved in apoptosis.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalIn Vivo
Volume24
Issue number3
Publication statusPublished - May 1 2010

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Keywords

  • Biodiesel
  • Gadd45a
  • Gene expression
  • Glycerol
  • Nfκb1
  • Renewable energy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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