Feedback control of arterial smooth muscle tone: the role of prostacyclin

P. Hadházy, K. Magyar

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Indomethacin potentiated noradrenaline (NA)‐induced contractions of rabbit isolated mesenteric arteries. Mechanical removal of the endothelium did not influence its potentiating effect. Prostacyclin (PGI2) synthesis was stimulated by NA (0.1‐1.0 μmol 1−1) and inhibited by indomethacin in a concentration‐dependent manner. There was a positive correlation between the indomethacin‐induced inhibition of PGI2 formation and the indomethacin‐evoked potentiation of contractile responses to NA. These results suggest that endogenous PGI2 plays a part in the feedback control of vascular smooth muscle tone. 1986 British Pharmacological Society

Original languageEnglish
Pages (from-to)861-863
Number of pages3
JournalBritish journal of pharmacology
Issue number4
Publication statusPublished - Dec 1986


ASJC Scopus subject areas

  • Pharmacology

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