Feedback control of arterial smooth muscle tone: the role of prostacyclin

P. Hadházy, K. Magyar

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Abstract

Indomethacin potentiated noradrenaline (NA)‐induced contractions of rabbit isolated mesenteric arteries. Mechanical removal of the endothelium did not influence its potentiating effect. Prostacyclin (PGI2) synthesis was stimulated by NA (0.1‐1.0 μmol 1−1) and inhibited by indomethacin in a concentration‐dependent manner. There was a positive correlation between the indomethacin‐induced inhibition of PGI2 formation and the indomethacin‐evoked potentiation of contractile responses to NA. These results suggest that endogenous PGI2 plays a part in the feedback control of vascular smooth muscle tone. 1986 British Pharmacological Society

Original languageEnglish
Pages (from-to)861-863
Number of pages3
JournalBritish journal of pharmacology
Volume89
Issue number4
DOIs
Publication statusPublished - Dec 1986

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ASJC Scopus subject areas

  • Pharmacology

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