Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida

Melinda Kovács, Roland Pósa, T. Tuboly, Tamás Donkó, I. Repa, János Tossenberger, Judit Szabó-Fodor, Stoycho Stoev, Tibor Magyar

Research output: Contribution to journalArticle

Abstract

The possible interaction between Pasteurella multocida and the mycotoxin fumonisin B1 (FB1), recognised as one of the most often food/feed contaminant, was studied with the aim to evaluate whether and how FB1 can influence and/or complicate the development and severity of various pathological damages provoked by Pasteurella multocida in some internal organs of pigs. Heavier lung pathology was seen in pigs experimentally infected with Pasteurella multocida, when the same were exposed to 20 ppm dietary levels of fumonisin B1 (FB1) as was assessed by gross pathology, pathomorphological examinations, clinical biochemistry and some immunological investigations. The most typical damages in FB1 treated pigs were the strong oedema in the lung and the slight oedema in the other internal organs and mild degenerative changes in the kidneys, whereas the typical pathomorphological findings in pigs infected with Pasteurella multocida was broncho-interstitial pneumonia. FB1 was found to aggravate pneumonic changes provoked by P. multocida in the cranial lobes of the lung and to complicate pneumonic damages with interstitial oedema in the lung. No macroscopic damages were observed in the pigs infected only with Pasteurella multocida. It can be concluded that the feed intake of FB1 in pigs may complicate or exacerbate the course of P. multocida serotype A infection.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalResearch in Veterinary Science
Volume108
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

Pasteurella multocida
fumonisin B1
Swine
lungs
Lung
swine
edema
Edema
Pathology
feed contamination
Mycotoxins
Interstitial Lung Diseases
Biochemistry
biochemistry
clinical examination
mycotoxins
pneumonia
serotypes
feed intake
kidneys

Keywords

  • Clinical chemistry
  • Fumonisin B
  • Immune response
  • Pasteurella multocida
  • Pathomorphology
  • Pigs

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida. / Kovács, Melinda; Pósa, Roland; Tuboly, T.; Donkó, Tamás; Repa, I.; Tossenberger, János; Szabó-Fodor, Judit; Stoev, Stoycho; Magyar, Tibor.

In: Research in Veterinary Science, Vol. 108, 01.10.2016, p. 38-46.

Research output: Contribution to journalArticle

Kovács, M, Pósa, R, Tuboly, T, Donkó, T, Repa, I, Tossenberger, J, Szabó-Fodor, J, Stoev, S & Magyar, T 2016, 'Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida', Research in Veterinary Science, vol. 108, pp. 38-46. https://doi.org/10.1016/j.rvsc.2016.07.011
Kovács, Melinda ; Pósa, Roland ; Tuboly, T. ; Donkó, Tamás ; Repa, I. ; Tossenberger, János ; Szabó-Fodor, Judit ; Stoev, Stoycho ; Magyar, Tibor. / Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida. In: Research in Veterinary Science. 2016 ; Vol. 108. pp. 38-46.
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