Features of the interaction between cyclodextrins and colloidal liposomes

I. Puskás, L. Barcza, L. Szente, F. Csempesz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Interactions in aqueous dispersion between dipalmitoyl phosphatidyl choline (DPPC) liposomes and dissolved cyclodextrins (CD) of different chemical compositions, respectively, were studied. Liposomal dispersions with small unilamellar vesicles (SUV) of monomodal size distribution were prepared and the physical stability of the vesicles both in the presence and absence of cyclodextrin was investigated. For the characterization of the kinetic stability of the dispersions under various conditions, size-distribution functions determined by photon-correlation spectroscopy (PCS) were used. The affinity of cyclodextrins to the liposomes was characterized by 'binding isotherms' determined under equilibrium conditions at 25°C. Based on the quantity of the cyclodextrins bound to the DPPC bilayers, stability constants for the associates were estimated. The physical stability of the liposomes and the possible control of stability were also investigated.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Inclusion Phenomena
Volume54
Issue number1-2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

cyclodextrins
Cyclodextrins
Liposomes
choline
Phosphatidylcholines
Dispersions
interactions
Unilamellar Liposomes
Photon correlation spectroscopy
Photons
spectroscopy
Spectrum Analysis
chemical composition
Distribution functions
Isotherms
affinity
isotherms
kinetics
distribution functions
Kinetics

Keywords

  • Cyclodextrin
  • Dipalmitoyl phosphatidyl choline
  • Liposome
  • Stability
  • Stability constant

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Features of the interaction between cyclodextrins and colloidal liposomes. / Puskás, I.; Barcza, L.; Szente, L.; Csempesz, F.

In: Journal of Inclusion Phenomena, Vol. 54, No. 1-2, 02.2006, p. 89-93.

Research output: Contribution to journalArticle

Puskás, I. ; Barcza, L. ; Szente, L. ; Csempesz, F. / Features of the interaction between cyclodextrins and colloidal liposomes. In: Journal of Inclusion Phenomena. 2006 ; Vol. 54, No. 1-2. pp. 89-93.
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