FDG PET imaging in hereditary thyroid cancer

A. Boér, S. Szakáll, I. Klein, M. Kásler, B. Vincze, L. Trón, M. Gödény, H. Herzog, I. Péter, Olga Ésik

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: To report the role of different imaging methods in staging individuals with multiple endocrine neoplasia 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC). Material and Methods: Fourteen newly diagnosed gene carriers underwent cervical ultrasound scanning (US), cervical and mediastinal CT, MRI and whole-body meta-[131]iodobenzylguanidine (MIBG) scintigraphy and [18F]fluorodeoxyglucose (FDG) PET scanning. Results: US identified seven true primary cancer. CT and MRI located only tumors ≥ 5 mm in diameter. MIBG scintigraphy and FDG PET could not identify MTC foci within the thyroid. Whole-body FDG PET identified two true-positive and one false-positive lymph node metastases. MIBG scintigraphy did not identify lymph node metastases. Total thyroidectomy was performed in 12 cases, and subtotal thyroidectomy in two subjects. Conclusions: Whole-body FDG PET and cervical US help stage individuals carrying mutant genes verifying MEN2A or FMTC.

Original languageEnglish
Pages (from-to)922-928
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume29
Issue number10
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Familial medullary thyroid carcinoma
  • Multiple endocrine neoplasia type 2
  • Positron emission tomography
  • RET proto-oncogene
  • Thyroidectomy
  • Ultrasonography

ASJC Scopus subject areas

  • Surgery
  • Oncology

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