FDG, MET or CHO? The quest for the optimal PET tracer for glioma imaging continues

Balázs Gulyás, I. Nyáry, Katalin Borbély

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This Practice Point commentary discusses a study by Kato et al. that assessed the usefulness of three PET tracers-11C-methionine (MET), 18F-fluorodeoxyglucose, and 11C-choline-for the metabolic evaluation of gliomas. The authors measured the ratio of tumor uptake to normal brain uptake (T/N ratio), with the frontal cortex as reference region, and analyzed the correlations between tracer uptake and tumor grade, type, and proliferation activity. Whereas all three tracers showed a similar correlation between the T/N ratio and tumor grade in astrocytic and oligodendroglial tumors, MET proved to be the most user-friendly marker in all gliomas as it enables the straightforward localization of 'hot lesions' and provides outstanding quantitative metabolic parameters. Here we highlight a few methodological issues arising from Kato et al.'s study and, consequently, we urge the PET community to reach a consensus on an objective approach towards the evaluation of PET tracers in the field of neuro-oncology.

Original languageEnglish
Pages (from-to)470-471
Number of pages2
JournalNature Clinical Practice Neurology
Volume4
Issue number9
DOIs
Publication statusPublished - 2008

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Glioma
Methionine
Neoplasms
Fluorodeoxyglucose F18
Frontal Lobe
Choline
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

FDG, MET or CHO? The quest for the optimal PET tracer for glioma imaging continues. / Gulyás, Balázs; Nyáry, I.; Borbély, Katalin.

In: Nature Clinical Practice Neurology, Vol. 4, No. 9, 2008, p. 470-471.

Research output: Contribution to journalArticle

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