Fc receptors of rat peritoneal macrophages: Immunoglobulin class specificity and sensitivity to drugs affecting the microfilament or microtubule system

G. A. Medgyesi, G. Foris, B. Dezső, J. Gergely, H. Bazin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Macrophage-cytophilic antibody activity of various immunoglobulin classes and subclasses was tested in two different rosetting systems. Cytophilic antibody activity of IgM, IgG2a and IgG1 was verified in the SRBC system, while IgM, IgG2a and IgG2c were found to be active in the trypanosome system. Sensitivity to cytochalasin B treatment of SRBC rosette formation was dependent on the class of antibody and decreased in the following order: IgM > IgG1 > IgG2a. Trypanosome rosette formation was prevented by the same drug regardless the type of antibody. Vinblastin caused an enhancement of rosette formation in the SRBC system in low concentration, except when the antibody belonged to subclass IgG1. The enhancing effect was less pronounced in the trypanosome system.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalImmunology
Volume40
Issue number3
Publication statusPublished - 1980

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Fc Receptors
Immunoglobulin Isotypes
Peritoneal Macrophages
Actin Cytoskeleton
Rosette Formation
Microtubules
Trypanosomiasis
Immunoglobulin M
Sensitivity and Specificity
Antibodies
Immunoglobulin G
Pharmaceutical Preparations
Cytochalasin B
Macrophages

ASJC Scopus subject areas

  • Immunology

Cite this

Fc receptors of rat peritoneal macrophages : Immunoglobulin class specificity and sensitivity to drugs affecting the microfilament or microtubule system. / Medgyesi, G. A.; Foris, G.; Dezső, B.; Gergely, J.; Bazin, H.

In: Immunology, Vol. 40, No. 3, 1980, p. 317-323.

Research output: Contribution to journalArticle

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