Fc receptors in livestock species

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Many of the receptors for the Fc domain of immunoglobulins in cattle, sheep, pigs and horses have been cloned and characterized recently. This review summarises recent developments and relates them to the current understanding of the primary structure, cellular specificity and binding properties of Fc receptors (FcRs). Although there is an obvious overall similarity to their human and mouse counterparts, some Fc receptors in domestic animals are unusual, perhaps most notably the bovine Fcγ2R, which although related to other mammalian FcγRs, belongs to a novel gene family and the porcine FcγRIIIA, which associates with a molecule that contains significant homology to the cathelin family of antimicrobial proteins. Accumulating data suggest the possibility of a different role for the FcRn in ruminants, which may secrete IgG onto the mucosal surfaces, rather than absorbing it, as was suggested by mouse studies. These differences may be linked to the diversity of immunoglobulin classes in different mammalian species, and may contribute to different immune functions. The observations made so far emphasize the importance of elucidating and analyzing the roles of these molecules within the immune system of each host animal, rather than inferring roles from conclusions made in human and mouse studies. A better understanding of Fc receptor expression on immune effector cells should help in developing new immunization protocols, while knowledge of the Fc receptors involved in immunoglobulin transport, especially in the mammary gland, may help to develop new products which could be used not only for veterinary purposes but perhaps also for human therapy.

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalVeterinary Immunology and Immunopathology
Volume102
Issue number4
DOIs
Publication statusPublished - Dec 28 2004

Fingerprint

Fc Receptors
Livestock
livestock
receptors
Swine
immunoglobulins
mice
Immunoglobulin Fc Fragments
Immunoglobulin Isotypes
antimicrobial proteins
Domestic Animals
Ruminants
Cellular Structures
Human Mammary Glands
swine
binding properties
cattle
cell structures
new products
Horses

Keywords

  • Domestic animals
  • Fc receptors
  • Immunoglobulins

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Fc receptors in livestock species. / Kacskovics, I.

In: Veterinary Immunology and Immunopathology, Vol. 102, No. 4, 28.12.2004, p. 351-356.

Research output: Contribution to journalArticle

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