FcγR‐Dependent Regulation of the Biosynthesis of Complement C3 by Murine Macrophages: the Modulatory Effect of IL‐6

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Abstract

The effect of murine IgG isotypes on the gene expression and secretion of the third component of complement (C3) has been studied using the monocytoid cell line P388DI and oil‐elicited mouse peritoneal macrophages. It is demonstrated that the binding of IgG2a and IgG2b but not IgG1 and IgG3 augments the biosynthesis of C3 both in the presence and in the absence of the phorbol ester. phorbol myristate acetate in the case of both cell types. The multifunctional cytokine inlerleukin‐6 (IL‐6) alone reveals no effect on the gene expression of C3, but increases the effectiveness of mouse IgG2a and IgG2b. Confirming the role of FcγRII, a strong up‐regulation of C3 gene expression and C3 secretion was found when macrophages were cultured with the F(ab')2; fragment of the FcγRII‐specific monoclonal antibody 2.4G2.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalScandinavian Journal of Immunology
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 1992

ASJC Scopus subject areas

  • Immunology

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