Fatty degeneration in cultured hepatocytes - A new experimental model

Gabor Vajta, András Divald, Sándor Paku, Jeno Elek, Károly Lapis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In co-cultures of adult rat hepatocytes and a neonatal rat liver cell line, severe fatty degeneration was induced by the addition of 50% rat serum. The light and electron microscopic patterns did not differ significantly from those of in vivo fatty degeneration and the changes were reversible on removal of the serum. The in vitro system is considered to simulate some forms of fatty degeneration of the liver and to be suitable for testing the effects of liver-protecting agents.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume52
Issue number1
DOIs
Publication statusPublished - Dec 1 1986

Keywords

  • Fatty degeneration
  • Hepatocyte culture

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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